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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2019-12-169-174</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-3446</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Роль Helicobacter Pylori в механизмах кардио- и вазотоксичности</article-title><trans-title-group xml:lang="en"><trans-title>The role of Helicobacter pylori in cardiovascular toxicity mechanisms</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5383-8355</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авагимян</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Avagimyan</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ашот Арманович Авагимян — студент 5-го курса факультета общей медицины</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">Avagimyan.cardiology@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5357-1518</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мкртчян</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Mkrtchyan</surname><given-names>L. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Люсине Генриховна Мкртчян — к.м.н., доцент кафедры кардиологии</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">mph75.78@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9476-4535</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Навасардян</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Navasardyan</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гризельда Асатуровна Навасардян — к.м.н., профессор кафедры патофизиологии</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">mph75.75@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6181-1358</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Геворкян</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gevorkyan</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Астхик Артаваздовна Геворкян — преподаватель кафедры внутренних болезней</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">mph76.76@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1407-3855</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ананян</surname><given-names>Э. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ananyan</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эмма Андреевна Ананян. — к.м.н., доцент кафедры пропедевтики внутренних болезней</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">lala.lamprinidis@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2203-0406</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пашинян</surname><given-names>Н. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Pashinyan</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нарине Эдуардовна Пашинян — к.м.н., доцент кафедры гастроэнтерологии и гепатологии</p><p>Ереван</p></bio><bio xml:lang="en"/><email xlink:type="simple">harut1997har3@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6757-447X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абгарян</surname><given-names>К. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Abgaryan</surname><given-names>K. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кристина Генриховна Абгарян — к.м.н., доцент кафедры микробиологии, иммунологии, вирусологии</p><p>Ереван</p><p> </p></bio><bio xml:lang="en"/><email xlink:type="simple">kentukiboild6@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ереванский Государственый Медицинский Университет имени Мхитара Гераци</institution><country>Армения</country></aff><aff xml:lang="en"><institution>Yerevan State Medical University</institution><country>Armenia</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Ереванский Государственный Медицинский Университет имени Мхитара Гераци</institution><country>Армения</country></aff><aff xml:lang="en"><institution>Yerevan State Medical University</institution><country>Armenia</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>18</day><month>09</month><year>2019</year></pub-date><volume>0</volume><issue>12</issue><fpage>169</fpage><lpage>174</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Авагимян А.А., Мкртчян Л.Г., Навасардян Г.А., Геворкян А.А., Ананян Э.А., Пашинян Н.Э., Абгарян К.Г., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Авагимян А.А., Мкртчян Л.Г., Навасардян Г.А., Геворкян А.А., Ананян Э.А., Пашинян Н.Э., Абгарян К.Г.</copyright-holder><copyright-holder xml:lang="en">Avagimyan A.A., Mkrtchyan L.G., Navasardyan G.A., Gevorkyan A.A., Ananyan E.A., Pashinyan N.E., Abgaryan K.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/3446">https://russjcardiol.elpub.ru/jour/article/view/3446</self-uri><abstract><p>Несмотря на длительное существование инфекционной теории развития сердечно-сосудистых заболеваний (атеросклероза в частности), данная концепция переживает настоящий бум, представляя собой весомый интерес.</p><p>В данной статье обсуждается вопрос роли высокоинвазивного бактериального канцерогена H. pylori, в механизмах, направленных на дестабилизацию сердечно-сосудистого гомеостаза. Роль данной бактерии в развитии атерогенного поражения артерий эластического и мышечно-эластического типа и/или дестабилизации уже существующей атеромы на сегодняшний день не представляет никаких сомнений. Доказательства в виде клинических исследований подробно описаны в статье.</p></abstract><trans-abstract xml:lang="en"><p>Despite the long history of the concept where infection plays a significant role in cardiovascular diseases (atherosclerosis in particular), today it is relevant and represented a significant interest.</p><p>This article discusses H. pylori role in mechanisms of cardiovascular homeostasis disturbance. H. pylori involvement in atherogenic damage of arteries, and/or plaque destabilization is no doubt. This vidence is detailed in this review article.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиотоксичность</kwd><kwd>вазотоксичность</kwd><kwd>H. pylori</kwd><kwd>атерогенез.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular toxicity</kwd><kwd>H. pylori</kwd><kwd>atherogenesis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Navasardyan G. Textbook of fundamental pathophysiology. Yerevan State Medical University PRESS. Yerevan, RA. 2018. (In Armenian). ISBN 978-9939-65-127-9.</mixed-citation><mixed-citation xml:lang="en">Navasardyan G. Textbook of fundamental pathophysiology. Yerevan State Medical University PRESS. Yerevan, RA. 2018. (In Armenian). ISBN 978-9939-65-127-9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Yuan X, Wang Y, Wang M. The type IV secretion system in Helicobacter pylori. Future Microbiol. 2018;13(2):1041-54. doi:10.2217/fmb-2018-0038.</mixed-citation><mixed-citation xml:lang="en">Yuan X, Wang Y, Wang M. The type IV secretion system in Helicobacter pylori. Future Microbiol. 2018;13(2):1041-54. doi:10.2217/fmb-2018-0038.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Itani H, McMaster W, Saleh M, et al. Activation of human T cells in hypertension: studies of humanized mice and hypertensive humans. Hypertension. 2016;68(1):123-32. doi:10.1161/HYPERTENSIONAHA.116.07237.</mixed-citation><mixed-citation xml:lang="en">Itani H, McMaster W, Saleh M, et al. Activation of human T cells in hypertension: studies of humanized mice and hypertensive humans. Hypertension. 2016;68(1):123-32. doi:10.1161/HYPERTENSIONAHA.116.07237.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Pavlov ON. Inflammation and increasing H. pylori antibody titers in acute coronary syndrome. Russian Journal of Cardiology. 2011;(6):43-6. (In Russ.) Павлов О.Н. Связь воспаления с ростом титра антител к H. pylori при остром коронарном синдроме. Российский кардиологический журнал. 2011;(6):43-6. doi:10.15829/1560-4071-2011-6-78-82.</mixed-citation><mixed-citation xml:lang="en">Pavlov ON. Inflammation and increasing H. pylori antibody titers in acute coronary syndrome. Russian Journal of Cardiology. 2011;(6):43-6. (In Russ.) Павлов О.Н. Связь воспаления с ростом титра антител к H. pylori при остром коронарном синдроме. Российский кардиологический журнал. 2011;(6):43-6. doi:10.15829/1560-4071-2011-6-78-82.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mejias R, Lozano P, Wanisch A, et al. Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. Sci Rep. 2019;9(1):70-4. doi:10.1038/s41598-019-43417-x.</mixed-citation><mixed-citation xml:lang="en">Mejias R, Lozano P, Wanisch A, et al. Increased LIGHT expression and activation of non-canonical NF-κB are observed in gastric lesions of MyD88-deficient mice upon Helicobacter felis infection. Sci Rep. 2019;9(1):70-4. doi:10.1038/s41598-019-43417-x.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Pasparakis M. Role of NF-κB in epithelial biology. Immunol Rev. 2012;246(1):346-58. doi:10.1111/j.1600-065X.2012.01109.x.</mixed-citation><mixed-citation xml:lang="en">Pasparakis M. Role of NF-κB in epithelial biology. Immunol Rev. 2012;246(1):346-58. doi:10.1111/j.1600-065X.2012.01109.x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Park K, Byun H, Won M, et al. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Carcinogenesis. 2007 Jan;28(1):71-80. doi:10.1093/carcin/bgl094.</mixed-citation><mixed-citation xml:lang="en">Park K, Byun H, Won M, et al. Sustained activation of protein kinase C downregulates nuclear factor-kappaB signaling by dissociation of IKK-gamma and Hsp90 complex in human colonic epithelial cells. Carcinogenesis. 2007 Jan;28(1):71-80. doi:10.1093/carcin/bgl094.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nina V, Ute A, Julia B, et al. Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study. Front Public Health. 2019;24(7):96-104. doi:10.3389/fpubh.2019.00096. eCollection 2019.</mixed-citation><mixed-citation xml:lang="en">Nina V, Ute A, Julia B, et al. Helicobacter pylori Seropositivity: Prevalence, Associations, and the Impact on Incident Metabolic Diseases/Risk Factors in the Population-Based KORA Study. Front Public Health. 2019;24(7):96-104. doi:10.3389/fpubh.2019.00096. eCollection 2019.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chen L, Xu W, Lee A, et al. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial. EBioMedicine. 2018;35(1):87-96. doi:10.1016/j.ebiom.2018.08.028.</mixed-citation><mixed-citation xml:lang="en">Chen L, Xu W, Lee A, et al. The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial. EBioMedicine. 2018;35(1):87-96. doi:10.1016/j.ebiom.2018.08.028.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Avagimyan A. The novel visibility of myocarditis. From pathology to treatment. Aristotle Biomed J. 2019:1(1):32-47.</mixed-citation><mixed-citation xml:lang="en">Avagimyan A. The novel visibility of myocarditis. From pathology to treatment. Aristotle Biomed J. 2019:1(1):32-47.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Masahiro K, Junya Tanaka, Nobuhiro A, et al. Helicobacter pylori Promotes the Production of Thymic Stromal Lymphopoietin by Gastric Epithelial Cells and Induces Dendritic Cell-Mediated Inflammatory Th2 Responses. Infect Immun. 2010;78(1):108-14. doi:10.1128/IAI.00762-09.</mixed-citation><mixed-citation xml:lang="en">Masahiro K, Junya Tanaka, Nobuhiro A, et al. Helicobacter pylori Promotes the Production of Thymic Stromal Lymphopoietin by Gastric Epithelial Cells and Induces Dendritic Cell-Mediated Inflammatory Th2 Responses. Infect Immun. 2010;78(1):108-14. doi:10.1128/IAI.00762-09.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Xu Y, Huang D, Lü S, et al. Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils. APL Bioeng. 2019;28(1):104-22. doi:10.1063/1.5045115.</mixed-citation><mixed-citation xml:lang="en">Xu Y, Huang D, Lü S, et al. Mechanical features of endothelium regulate cell adhesive molecule-induced calcium response in neutrophils. APL Bioeng. 2019;28(1):104-22. doi:10.1063/1.5045115.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zaph C, Troy E, Taylor, et al. Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis. Nature 2007;446(4):552-6.</mixed-citation><mixed-citation xml:lang="en">Zaph C, Troy E, Taylor, et al. Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis. Nature 2007;446(4):552-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Francisco V, Ruiz-Fernández C, Pino J et al. Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;52(9):16-9. doi:10.1016/j.bcp.2019.03.030.</mixed-citation><mixed-citation xml:lang="en">Francisco V, Ruiz-Fernández C, Pino J et al. Adipokines: linking metabolic syndrome, the immune system, and arthritic diseases. Biochem Pharmacol. 2019;52(9):16-9. doi:10.1016/j.bcp.2019.03.030.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Tay M, Lim S, Leong Y, et al. Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia. Front Immunol. 2019;27(10):5705. doi:10.3389/fimmu.2019.00575.</mixed-citation><mixed-citation xml:lang="en">Tay M, Lim S, Leong Y, et al. Halted Lymphocyte Egress via Efferent Lymph Contributes to Lymph Node Hypertrophy During Hypercholesterolemia. Front Immunol. 2019;27(10):5705. doi:10.3389/fimmu.2019.00575.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ilze B, Guo S, Petri T. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;35(2):265-71. doi:10.1161/ATVBAHA.114.303570.</mixed-citation><mixed-citation xml:lang="en">Ilze B, Guo S, Petri T. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2016;35(2):265-71. doi:10.1161/ATVBAHA.114.303570.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hamed S, Amine N, Galal G, et al. Vascular risks and complications in diabetes mellitus: the role of helicobacter pylori infection. J Stroke Cerebrovasc Dis. 2008;17(2):86-94. doi:10.1016/j.jstrokecerebrovasdis.2007.10.006.</mixed-citation><mixed-citation xml:lang="en">Hamed S, Amine N, Galal G, et al. Vascular risks and complications in diabetes mellitus: the role of helicobacter pylori infection. J Stroke Cerebrovasc Dis. 2008;17(2):86-94. doi:10.1016/j.jstrokecerebrovasdis.2007.10.006.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Paul G, Sreyoshi F. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14:6. doi:10.1186/1475-2891-14-6.</mixed-citation><mixed-citation xml:lang="en">Paul G, Sreyoshi F. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;14:6. doi:10.1186/1475-2891-14-6.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mędrek M, Chojnacki J, Smigielski J et al. Changes in the lipid profile of patients with asymptomatic and symptomatic helicobacter pylori infection. Wiad Lek. 2018;71(8):1467-73.</mixed-citation><mixed-citation xml:lang="en">Mędrek M, Chojnacki J, Smigielski J et al. Changes in the lipid profile of patients with asymptomatic and symptomatic helicobacter pylori infection. Wiad Lek. 2018;71(8):1467-73.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Choi J, Lim S, Han Y, et al. Association between Helicobacter pylori infection and arterial stiffness: Results from a large cross-sectional study. PLoS One. 2019;14(8):16-23. doi:10.1371/journal.pone.0221643.</mixed-citation><mixed-citation xml:lang="en">Choi J, Lim S, Han Y, et al. Association between Helicobacter pylori infection and arterial stiffness: Results from a large cross-sectional study. PLoS One. 2019;14(8):16-23. doi:10.1371/journal.pone.0221643.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Gomez L, Garcia L, Patino M, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016;15(1):148. doi:10.1186/s12933-016-0465-7.</mixed-citation><mixed-citation xml:lang="en">Gomez L, Garcia L, Patino M, et al. Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial. Cardiovasc Diabetol. 2016;15(1):148. doi:10.1186/s12933-016-0465-7.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Yang S, Xia Y, Luo X, et al. Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis. J Mol Cell Cardiol. 2019;135(3):40-51. doi:10.1016/j.yjmcc.2019.07.011.</mixed-citation><mixed-citation xml:lang="en">Yang S, Xia Y, Luo X, et al. Exosomal CagA derived from Helicobacter pylori-infected gastric epithelial cells induces macrophage foam cell formation and promotes atherosclerosis. J Mol Cell Cardiol. 2019;135(3):40-51. doi:10.1016/j.yjmcc.2019.07.011.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kowalski M. Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol. 2001;52(1):3-31.</mixed-citation><mixed-citation xml:lang="en">Kowalski M. Helicobacter pylori (H. pylori) infection in coronary artery disease: influence of H. pylori eradication on coronary artery lumen after percutaneous transluminal coronary angioplasty. The detection of H. pylori specific DNA in human coronary atherosclerotic plaque. J Physiol Pharmacol. 2001;52(1):3-31.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Shan J, Bai X, Han L, et al. Association between atherosclerosis and gastric biomarkers concerning Helicobacter pylori infection in a Chinese healthy population. Exp Gerontol. 2018;112(2):97-102. doi:10.1016/j.exger.2018.09.009.</mixed-citation><mixed-citation xml:lang="en">Shan J, Bai X, Han L, et al. Association between atherosclerosis and gastric biomarkers concerning Helicobacter pylori infection in a Chinese healthy population. Exp Gerontol. 2018;112(2):97-102. doi:10.1016/j.exger.2018.09.009.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Pantea M, Negovan A, Voidãzan S, et al. Statins and gastroduodenal endoscopic lesions: A case-control study. Medicine (Baltimore). 2018;97(50):13-25. doi:10.1097/MD.0000000000013579.</mixed-citation><mixed-citation xml:lang="en">Pantea M, Negovan A, Voidãzan S, et al. Statins and gastroduodenal endoscopic lesions: A case-control study. Medicine (Baltimore). 2018;97(50):13-25. doi:10.1097/MD.0000000000013579.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Stone A, Mendall M, Kaski J. Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation. 2002;106(10):1219-23.</mixed-citation><mixed-citation xml:lang="en">Stone A, Mendall M, Kaski J. Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation. 2002;106(10):1219-23.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Feng L, Deng C, Li Y. Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection. Dis Markers. 2018:201(1):37-93. doi:10.1155/2018/3793768.</mixed-citation><mixed-citation xml:lang="en">Feng L, Deng C, Li Y. Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection. Dis Markers. 2018:201(1):37-93. doi:10.1155/2018/3793768.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Lee M, Baek H, Park J, et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018 Mar 2;13(3):e0193646. doi:10.1371/journal.pone.0193646.</mixed-citation><mixed-citation xml:lang="en">Lee M, Baek H, Park J, et al. Current Helicobacter pylori infection is significantly associated with subclinical coronary atherosclerosis in healthy subjects: A cross-sectional study. PLoS One. 2018 Mar 2;13(3):e0193646. doi:10.1371/journal.pone.0193646.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">He C, Yang Z, Lu N. Helicobacter pylori-an infectious risk factor for atherosclerosis? J Atheroscler Thromb. 2014;21(12):1229-42. Epub 2014 Oct 24.</mixed-citation><mixed-citation xml:lang="en">He C, Yang Z, Lu N. Helicobacter pylori-an infectious risk factor for atherosclerosis? J Atheroscler Thromb. 2014;21(12):1229-42. Epub 2014 Oct 24.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Karadag Z, Sehitoglu T, Cure M, et al. Helicobacter pylori can be related to carotid intimamedia thickness, epicardial adipose tissue thickness and serum neutrophil gelatinaseassociated lipocalin (NGAL) levels. Bratisl Lek Listy. 2018;119(5):302-7. doi:10.4149/BLL_2018_057.</mixed-citation><mixed-citation xml:lang="en">Karadag Z, Sehitoglu T, Cure M, et al. Helicobacter pylori can be related to carotid intimamedia thickness, epicardial adipose tissue thickness and serum neutrophil gelatinaseassociated lipocalin (NGAL) levels. Bratisl Lek Listy. 2018;119(5):302-7. doi:10.4149/BLL_2018_057.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Авагимян А, Ананян Э, Джндоян З, Навасардян Г. Современные представления о патогенных развитиях атерогенеза. Медицинская Наука Армении. 2019:78(1):3-29.</mixed-citation><mixed-citation xml:lang="en">Avagimyan A, Ananyan E, Djndoyan Z, Navasardyan G. The modern visibility of atherosclerosis development. Med News Armenia J. 2019;78(1):3-29. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Xu Z, Li J, Wang H, et al. Helicobacter pylori infection and atherosclerosis: is there a causal relationship? Eur J Clin Microbiol Infect Dis. 2017;36(12):2293-301. doi:10.1007/s10096017-3054-0.</mixed-citation><mixed-citation xml:lang="en">Xu Z, Li J, Wang H, et al. Helicobacter pylori infection and atherosclerosis: is there a causal relationship? Eur J Clin Microbiol Infect Dis. 2017;36(12):2293-301. doi:10.1007/s10096017-3054-0.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mkrtchyan L. A textbook of atherosclerosis. Yerevan State Medical University PRESS. Yerevan, RA. 2019. (In Armenian). ISBN 978-9939-65-140-8.</mixed-citation><mixed-citation xml:lang="en">Mkrtchyan L. A textbook of atherosclerosis. Yerevan State Medical University PRESS. Yerevan, RA. 2019. (In Armenian). ISBN 978-9939-65-140-8.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Johansen H, Norgaard A, Andersen L, et al. Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori. Clin Diagn Lab Immunol. 1995;2(2):149-55.</mixed-citation><mixed-citation xml:lang="en">Johansen H, Norgaard A, Andersen L, et al. Cross-reactive antigens shared by Pseudomonas aeruginosa, Helicobacter pylori, Campylobacter jejuni, and Haemophilus influenzae may cause false-positive titers of antibody to H. pylori. Clin Diagn Lab Immunol. 1995;2(2):149-55.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
