russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2019-7-103-109russjcardiol-3268Research ArticleОБЗОРЫREVIEWФибрилляция предсердий и гастроэзофагеальная болезнь: механизмы взаимосвязи, подходы к лечениюAtrial fibrillation and gastrooesophageal reflux disease: association mechanisms, treatment approacheshttps://orcid.org/0000-0002-6233-7202АнтроповаО. Н.AntropovaO. N.

Профессор кафедры факультетской терапии и профессиональных болезней.

Барнаул

Barnaul

antropovaon@mail.ruhttps://orcid.org/0000-0003-4387-7737ПыриковаН. В.PyrikovaN. V.

Пырикова Наталья Викторовна — профессор кафедры факультетской терапии и профессиональных болезней.

Barnaul

allinatali@mail.ruhttps://orcid.org/0000-0002-6845-6173ОсиповаИ. В.OsipovaI. V.

Осипова Ирина Владимировна — заведующий кафедрой факультетской терапии и профессиональных болезней.

Барнаул

Barnaul

i.v.osipova@gmail.comГБОУ ВПО Алтайский государственный медицинский университет Минздрава РФРоссияAltai State Medical UniversityRussian Federation20191708201907103109Copyright © Антропова О.Н., Пырикова Н.В., Осипова И.В., 20192019Антропова О.Н., Пырикова Н.В., Осипова И.В.Antropova O.N., Pyrikova N.V., Osipova I.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/3268

Статья посвящена оценке взаимосвязей фибрилляции предсердий (ФП) и гастроэзофагеальной рефлюксной болезни (ГЭРБ). Рассмотрены возможные анатомические взаимодействия, общность факторов риска и механизмы возникновения ФП у пациентов с гастроэзофагеальным рефлюксом. Продемонстрированы сложности лечения таких больных, поскольку ряд исследований доказали возможность применения ингибиторов протонной помпы при лечении ФП, в других наблюдениях получен аритмогенный эффект данной группы препаратов. Лечение ФП методом катетерной аблации, как правило, усугубляет течение ГЭРБ и может привести к развитию смертельных осложнений. Необходимы крупномасштабные проспективные исследования для дальнейшего и более детального изучения ассоциации ФП и ГЭРБ, а также тактики ведения таких пациентов.

The article is devoted to assessing the relationship of atrial fibrillation (AF) and gastroesophageal reflux disease (GERD). We studied possible anatomical correlations, common risk factors and mechanisms of AF development in patients with gastroesophageal reflux. We demonstrated the problems of the treatment of such patients, since a number of studies have proved the possibility of using proton pump inhibitors in the treatment of AF. In other cases the arrhythmogenic effect of these drugs was obtained. Treatment of AF by catheter ablation most commonly worsens the course of GORD and can lead to the development of fatal complications. Large-scale prospective researches are needed for further detailed study of AF and GERD associations, as well as tactics for management of these patients.

гастроэзофагеальная рефлюксная болезньингибиторы протонной помпырадиочастотная аблацияфибрилляция предсердийgastroesophageal reflux diseaseproton pump inhibitorsradiofrequency ablationatrial fibrillationReferencesBjorck S, Palaszewski B, Friberg L, et al. Atrial fibrillation, stroke risk, and warfarin therapy revisited: a population-based study. Stroke. 2013;44:3103-08. doi: 10.1161/STROKEAHA.113.002329.Bjorck S, Palaszewski B, Friberg L, et al. Atrial fibrillation, stroke risk, and warfarin therapy revisited: a population-based study. Stroke. 2013;44:3103-08. doi: 10.1161/STROKEAHA.113.002329.Haim M, Hoshen M, Reges O, et al. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident nonvalvular atrial fibrillation. J Am Heart Assoc. 2015;4:e001486. doi:10.1161/JAHA.114.001486.Haim M, Hoshen M, Reges O, et al. Prospective national study of the prevalence, incidence, management and outcome of a large contemporary cohort of patients with incident nonvalvular atrial fibrillation. J Am Heart Assoc. 2015;4:e001486. doi:10.1161/JAHA.114.001486.Colilla S, Crow A, Petkun W, et al. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112:1142-47. doi:10.1016/j.amjcard.2013.05.063.Colilla S, Crow A, Petkun W, et al. Estimates of current and future incidence and prevalence of atrial fibrillation in the U.S. adult population. Am J Cardiol. 2013;112:1142-47. doi:10.1016/j.amjcard.2013.05.063.Andersson T, Magnuson A, Bryngelsson IL, et al. All-cause mortality in 272,186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study. Eur Heart J. 2013;34:1061-67. doi:10.1093/eurheartj/ehs469.Andersson T, Magnuson A, Bryngelsson IL, et al. All-cause mortality in 272,186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study. Eur Heart J. 2013;34:1061-67. doi:10.1093/eurheartj/ehs469.Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal. 2016;37:2893-962. doi:10.15829/1560-4071-2017-7-7-86.Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. European Heart Journal. 2016;37:2893-962. doi:10.15829/1560-4071-2017-7-7-86.Шаповалова М. М. Гастроэзофагеальная рефлюксная болезнь и нейрогенные аритмии сердца (обзор литературы). Молодой ученый. 2014;5:165-7.Shapovalova MM. Gastroesophageal reflux disease and neurogenic cardiac arrhythmias (literature review). Young scientist. 2014;5:165-7. (In Russ.)Gerson LB, Friday K, Triadafilopoulos G. Potential relationship between gastroesophageal reflux disease and atrial arrhythmias. J Clin Gastroenterol. 2006;40:828-32. doi:10.1097/01.mcg.0000225571.42890.a5.Gerson LB, Friday K, Triadafilopoulos G. Potential relationship between gastroesophageal reflux disease and atrial arrhythmias. J Clin Gastroenterol. 2006;40:828-32. doi:10.1097/01.mcg.0000225571.42890.a5.Cuomo R, De Giorgi F, Adinolfi L, et al. Esophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias. Alimentary Pharmacol Ther. 2006;24:361-70. doi:10.1111/j.1365-2036.2006.02987.x.Cuomo R, De Giorgi F, Adinolfi L, et al. Esophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias. Alimentary Pharmacol Ther. 2006;24:361-70. doi:10.1111/j.1365-2036.2006.02987.x.Kunz JS, Hemann B, Edwin Atwood J, et al. Is there a link between gastroesophageal reflux disease and atrial fibrillation? Clin Cardiol. 2009;32:584-7. doi:10.1002/clc.20660.Kunz JS, Hemann B, Edwin Atwood J, et al. Is there a link between gastroesophageal reflux disease and atrial fibrillation? Clin Cardiol. 2009;32:584-7. doi:10.1002/clc.20660.Shimazu H, Nakaji G, Fukata M, et al. Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey. Cardiology. 2011;119:217-23. doi:10.1159/000331497.Shimazu H, Nakaji G, Fukata M, et al. Relationship between atrial fibrillation and gastroesophageal reflux disease: a multicenter questionnaire survey. Cardiology. 2011;119:217-23. doi:10.1159/000331497.Bunch TJ, Packer DL, Jahangir A, et al. Long-term risk of atrial fibrillation with symptomatic gastroesophageal reflux disease and esophagitis. Am J Cardiol. 2008;102:1207-11. doi:10.1016/j.amjcard.2008.06.048.Bunch TJ, Packer DL, Jahangir A, et al. Long-term risk of atrial fibrillation with symptomatic gastroesophageal reflux disease and esophagitis. Am J Cardiol. 2008;102:1207-11. doi:10.1016/j.amjcard.2008.06.048.Daoud EG, Hummel JD, Houmsse M, et al. Comparison of computed tomography imaging with intraprocedural contrast esophagram: implications for catheter ablation of atrial fibrillation. Heart Rhythm. 2008;5:975-80. doi:10.1016/j.hrthm.2008.03.058.Daoud EG, Hummel JD, Houmsse M, et al. Comparison of computed tomography imaging with intraprocedural contrast esophagram: implications for catheter ablation of atrial fibrillation. Heart Rhythm. 2008;5:975-80. doi:10.1016/j.hrthm.2008.03.058.Roy RR, Sagar S, Bunch TJ, et al. Hiatal hernia is associated with associated with an increased prevalence of atrial fibrillation in young patients. J Atr Fibrillation. 2013 ;6:894. doi:10.4022/jafib.894.Roy RR, Sagar S, Bunch TJ, et al. Hiatal hernia is associated with associated with an increased prevalence of atrial fibrillation in young patients. J Atr Fibrillation. 2013 ;6:894. doi:10.4022/jafib.894.Самсонов А. А., Юренева-Тхоржевская Т. В. Современный взгляд на кардиальные проявления гастроэзофагеальной рефлюксной болезни. Consilium Medicum. 2015;12:44-9.Samsonov AA, Yureneva-Tkhorzhevskaya TV. A modern view on the cardiac manifestations of gastroesophageal reflux disease. Consilium Medicum. 2015;12:44-9. (In Russ.)Linz D, Hohl V, Vollmar J, et al. Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction. Europace. 2017;19:16-20. doi:10.1093/europace/euw092.Linz D, Hohl V, Vollmar J, et al. Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction. Europace. 2017;19:16-20. doi:10.1093/europace/euw092.Schotten U, Verheule S, Kirchhof P, et al. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev. 2011;91:265-325. doi: 10.1152/physrev.00031.2009.Schotten U, Verheule S, Kirchhof P, et al. Pathophysiological mechanisms of atrial fibrillation: a translational appraisal. Physiol Rev. 2011;91:265-325. doi: 10.1152/physrev.00031.2009.Harada M, Van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circ J. 2015;79:495-502. doi:10.1253/circj.CJ-15-0138.Harada M, Van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circ J. 2015;79:495-502. doi:10.1253/circj.CJ-15-0138.Reddy YM, Singh D, Nagarajan D, et al. Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome-the heart to gut connection! J IntervCard Electrophysiol. 2013;37:259-65. doi:10.1007/s10840-013-9807-5.Reddy YM, Singh D, Nagarajan D, et al. Atrial fibrillation ablation in patients with gastroesophageal reflux disease or irritable bowel syndrome-the heart to gut connection! J IntervCard Electrophysiol. 2013;37:259-65. doi:10.1007/s10840-013-9807-5.Floria M, Drug VL. Atrial fibrillation and gastroesophageal reflux disease: From the cardiologist perspective. World J Gastroenterol. 2015;21(10):3154-56. doi:10.3748/wjg.v21.i10.31546.Floria M, Drug VL. Atrial fibrillation and gastroesophageal reflux disease: From the cardiologist perspective. World J Gastroenterol. 2015;21(10):3154-56. doi:10.3748/wjg.v21.i10.31546.Aldhoon B, Melenovsky V, Peichl P, et al. New insights into mechanisms of atrial fibrillation. Physiol Res. 2010;59:1-12.Aldhoon B, Melenovsky V, Peichl P, et al. New insights into mechanisms of atrial fibrillation. Physiol Res. 2010;59:1-12.Gutierrez A, Van Wagoner DR. Oxidant and inflammatory mechanisms and targeted therapy in atrial fibrillation. J Cardiovasc Pharmacol. 2015;66:523-9. doi:10.1097/FJC.0000000000000313.Gutierrez A, Van Wagoner DR. Oxidant and inflammatory mechanisms and targeted therapy in atrial fibrillation. J Cardiovasc Pharmacol. 2015;66:523-9. doi:10.1097/FJC.0000000000000313.Friedenberg FK, Xanthopoulos M, Foster GD, et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103:2111-22. doi:10.1111/j.1572-0241.2008.01946.x.Friedenberg FK, Xanthopoulos M, Foster GD, et al. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol. 2008;103:2111-22. doi:10.1111/j.1572-0241.2008.01946.x.Moki F, Kusano M, Mizuide M, et al. Association between reflux oesophagitis and features of the metabolic syndrome in Japan. Alimentary Pharmacol Ther. 2007;26:1069-75. doi:10.1111/j.1365-2036.2007.03454.x.Moki F, Kusano M, Mizuide M, et al. Association between reflux oesophagitis and features of the metabolic syndrome in Japan. Alimentary Pharmacol Ther. 2007;26:1069-75. doi:10.1111/j.1365-2036.2007.03454.x.Shepherd KL, James AL, Musk AW, et al. Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea. J Sleep Res. 2011;20:241-9. doi:10.1111/j.1365-2869.2010.00843.x.Shepherd KL, James AL, Musk AW, et al. Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea. J Sleep Res. 2011;20:241-9. doi:10.1111/j.1365-2869.2010.00843.x.Ayazi S, Tamhankar A, DeMeester SR, et al. The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice. Ann Surg. 2010;252:57-62. doi:10.1097/SLA.0b013e3181e3e411/.Ayazi S, Tamhankar A, DeMeester SR, et al. The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice. Ann Surg. 2010;252:57-62. doi:10.1097/SLA.0b013e3181e3e411/.Fioravanti F, Brisinda D, Sorbo AR, et al. Compliance in weight control reduces atrial fibrillation worsening: a retrospective cohort study. Nutr Metab Cardiovasc Dis. 2017;27:711-6. doi:10.1016/j.numecd.2017.04.007.Fioravanti F, Brisinda D, Sorbo AR, et al. Compliance in weight control reduces atrial fibrillation worsening: a retrospective cohort study. Nutr Metab Cardiovasc Dis. 2017;27:711-6. doi:10.1016/j.numecd.2017.04.007.Miller JD, Aronis KN, Chrispin J, et al. Obesity, exercise, obstructive sleep apnea, and modifiable atherosclerotic cardiovascular disease risk factors in atrial fibrillation. J Am Coll Cardiol. 2015;66:2899-906. doi:10.1016/j.jacc.2015.10.047.Miller JD, Aronis KN, Chrispin J, et al. Obesity, exercise, obstructive sleep apnea, and modifiable atherosclerotic cardiovascular disease risk factors in atrial fibrillation. J Am Coll Cardiol. 2015;66:2899-906. doi:10.1016/j.jacc.2015.10.047.Ивашкин В. Т., Маев И. В., Трухманов А. С. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению гастроэзофагеальной рефлюксной болезни. Российский журнал гастроэнтерологии, гепатологии и колопроктологии. 2017;27(4):75-95. doi:10.22416/1382-4376-2017-27-4-75-95.Ivashkin VT, Maev IV, Trukhmanov AS, et al. Clinical recommendations of the Russian Gastroenterological Association for the diagnosis and treatment of gastroesophageal reflux disease. RJGGK. 2017;27(4):75-95. (In Russ.) doi:10.22416/1382-4376-2017-27-4-75-95.Lin K, Chen X, Zhang L, et al. Proton pump inhibitors as also inhibitors of atrial fibrillation. Eur J Pharmacol. 2013;718:435-40. doi:10.1016/j.ejphar.2013.07.043.Lin K, Chen X, Zhang L, et al. Proton pump inhibitors as also inhibitors of atrial fibrillation. Eur J Pharmacol. 2013;718:435-40. doi:10.1016/j.ejphar.2013.07.043.Chen KP, Lee J, Mark RG, et al. Proton Pump Inhibitor Use Is Not Associated With Cardiac Arrhythmia in Critically Ill Patients. The Journal of Clinical Pharmacology. 2015;55(7):774-9. doi:10.1002/jcph.479.Chen KP, Lee J, Mark RG, et al. Proton Pump Inhibitor Use Is Not Associated With Cardiac Arrhythmia in Critically Ill Patients. The Journal of Clinical Pharmacology. 2015;55(7):774-9. doi:10.1002/jcph.479.Roman C, Bruley des Varannes S, Muresan L, et al. Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive review. World J Gastroenterol. 2014;20(28):9592-99. doi:12.3748/wjg.v20.i28.9592.Roman C, Bruley des Varannes S, Muresan L, et al. Atrial fibrillation in patients with gastroesophageal reflux disease: a comprehensive review. World J Gastroenterol. 2014;20(28):9592-99. doi:12.3748/wjg.v20.i28.9592.Alshekhani M. PPI: Non-Classical Uses. Gastroenterol Hepatol. 2017;6(4):00205. doi:10.15406/ghoa.2017.06.00205.Alshekhani M. PPI: Non-Classical Uses. Gastroenterol Hepatol. 2017;6(4):00205. doi:10.15406/ghoa.2017.06.00205.Min JY, Ocampo CJ, Kernet RC, et al. Omeprazole Has Anti-Inflammatory Effects on Type 2 Cytokine-Stimulated Human Airway Epithelial Cells. J Allergy Clin. Immunol. 2015;135(2):AB81. doi:10.1016/j.jaci.2014.12.1197.Min JY, Ocampo CJ, Kernet RC, et al. Omeprazole Has Anti-Inflammatory Effects on Type 2 Cytokine-Stimulated Human Airway Epithelial Cells. J Allergy Clin. Immunol. 2015;135(2):AB81. doi:10.1016/j.jaci.2014.12.1197.Sonoda Y, Teshima Y, Abe I, et al. Macrophage infiltration into the endothelium of atrial tissue in atrial fibrillation. Circ J. 2017;81:1742-44. doi:10.1253/circj.CJ-16-1072.Sonoda Y, Teshima Y, Abe I, et al. Macrophage infiltration into the endothelium of atrial tissue in atrial fibrillation. Circ J. 2017;81:1742-44. doi:10.1253/circj.CJ-16-1072.Jeremic N, Petkovic A, Srejovic I, et al. Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart. Braz J Cardiovasc Surg. 2015;30:266-75. doi:10.5935/1678-9741.20150020.Jeremic N, Petkovic A, Srejovic I, et al. Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart. Braz J Cardiovasc Surg. 2015;30:266-75. doi:10.5935/1678-9741.20150020.Huang CC, Chan WL, Luo JC, et al. Gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study. PLoS One. 2012;7:e47575. doi:10.1371/journal.pone.0047575.Huang CC, Chan WL, Luo JC, et al. Gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study. PLoS One. 2012;7:e47575. doi:10.1371/journal.pone.0047575.Odashiro K, Yasuda S, Yokoyama T, et al. Prevalence of gastroesophageal reflux disorder in arrhythmic patients and adjunctive effects of proton pump inhibitors on comorbid atrial fibrillation. Int J Basic Clin Pharmacol. 2015;4:644-50. doi:10.18203/2319-2003.ijbcp20150365.Odashiro K, Yasuda S, Yokoyama T, et al. Prevalence of gastroesophageal reflux disorder in arrhythmic patients and adjunctive effects of proton pump inhibitors on comorbid atrial fibrillation. Int J Basic Clin Pharmacol. 2015;4:644-50. doi:10.18203/2319-2003.ijbcp20150365.Marcus GM, Smith LM, Scheinman MM, et al. Proton pump inhibitors are associated with focal arrhythmias. J Innovations Card Rhythm Manage. 2010;1:85-9. doi:10.19102/icrm.2010.011206.Marcus GM, Smith LM, Scheinman MM, et al. Proton pump inhibitors are associated with focal arrhythmias. J Innovations Card Rhythm Manage. 2010;1:85-9. doi:10.19102/icrm.2010.011206.Sivakumar J. Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review. Int J Physiol Pathophysiol Pharmacol. 2016;8(4):169-74. doi:10.6065/apem.2012.17.4.249.Sivakumar J. Proton pump inhibitor-induced hypomagnesaemia and hypocalcaemia: case review. Int J Physiol Pathophysiol Pharmacol. 2016;8(4):169-74. doi:10.6065/apem.2012.17.4.249.William JH, Danziger J. Magnesium deficiency and proton-pump inhibitor use: a clinical review. J Clin Pharmacol. 2016;56:660-8. doi:101002/jcph.672.William JH, Danziger J. Magnesium deficiency and proton-pump inhibitor use: a clinical review. J Clin Pharmacol. 2016;56:660-8. doi:101002/jcph.672.Mikolasevic I, Milic S, Stimac D, et al. Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis? Eur J Intern Med. 2016;30:99-103. doi:10.1016/j.ejim.2016.01.026.Mikolasevic I, Milic S, Stimac D, et al. Is there a relationship between hypomagnesemia and proton-pump inhibitors in patients on chronic hemodialysis? Eur J Intern Med. 2016;30:99-103. doi:10.1016/j.ejim.2016.01.026.Ayuk J, Gittoes NJ. Treatment of hypomagnesemia. Am J Kidney Dis. 2014;63:691-5. doi:10.1053/j.ajkd.2013.07.025.Ayuk J, Gittoes NJ. Treatment of hypomagnesemia. Am J Kidney Dis. 2014;63:691-5. doi:10.1053/j.ajkd.2013.07.025.William JH, Danziger J. Proton-pump inhibitor-induced hypomagnesemia: current research and proposed mechanisms. World J Nephrol. 2016;5:152-7. doi:10.5527/wjn.v5.i2152.William JH, Danziger J. Proton-pump inhibitor-induced hypomagnesemia: current research and proposed mechanisms. World J Nephrol. 2016;5:152-7. doi:10.5527/wjn.v5.i2152.Atkinson NS, Reynolds DJ, Travis SP. “Lemonade legs”: why do some patients get profound hypomagnesaemia on proton-pump inhibitors? Intest Res. 2015;13:227-32. doi:10.5217/ir.2015.13.3.227.Atkinson NS, Reynolds DJ, Travis SP. “Lemonade legs”: why do some patients get profound hypomagnesaemia on proton-pump inhibitors? Intest Res. 2015;13:227-32. doi:10.5217/ir.2015.13.3.227.Diniotis B, Sternberg E, Shakuntala S, et al. Hypocalcemia in malignancy-unexpected but common. Cureus. 2015;7:e442. doi:10.7759/cureus.442.Diniotis B, Sternberg E, Shakuntala S, et al. Hypocalcemia in malignancy-unexpected but common. Cureus. 2015;7:e442. doi:10.7759/cureus.442.Toh JW, Ong E, Wilson R. Hypomagnesaemia associated with long-term use of proton pump inhibitors. Gastroenterol Rep (Oxf). 2015;3:243-53. doi:10.1093/gastro/gou054.Toh JW, Ong E, Wilson R. Hypomagnesaemia associated with long-term use of proton pump inhibitors. Gastroenterol Rep (Oxf). 2015;3:243-53. doi:10.1093/gastro/gou054.Knopp H, Halm U, Lamberts R. Incidental and ablation-induced findings during upper gastrointestinal endoscopy in patients after ablation of atrial fibrillation: a retrospective study of 425 patients. Heart Rhythm. 2014;11:574-8. doi:10.1016/j.hrthm.2014.01.010.Knopp H, Halm U, Lamberts R. Incidental and ablation-induced findings during upper gastrointestinal endoscopy in patients after ablation of atrial fibrillation: a retrospective study of 425 patients. Heart Rhythm. 2014;11:574-8. doi:10.1016/j.hrthm.2014.01.010.Tolone S, Savarino E, Docimo L. Radiofrequency Catheter Ablation for Atrial Fibrillation Elicited “Jackhammer Esophagus”: A New Complication Due to Vagal Nerve Stimulation? J Neurogastroenterol Motil. 2015;21(4):612-5. doi:10.5056/jnm15034.Tolone S, Savarino E, Docimo L. Radiofrequency Catheter Ablation for Atrial Fibrillation Elicited “Jackhammer Esophagus”: A New Complication Due to Vagal Nerve Stimulation? J Neurogastroenterol Motil. 2015;21(4):612-5. doi:10.5056/jnm15034.Maruyama T, Fukata M, Akashi K. Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases. J Arrhythm. 2018;35(1):43-51. doi:10.1002/joa3.12125.Maruyama T, Fukata M, Akashi K. Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases. J Arrhythm. 2018;35(1):43-51. doi:10.1002/joa3.12125.Chavez P, Messerli FH, Dominguez AC, et al. Atrioesophageal fistula following ablation procedures for atrial fibrillation: systematic review of case reports. Open Heart. 2015;2(1):e000257. doi:10.1136/openhrt-2015-000257.Chavez P, Messerli FH, Dominguez AC, et al. Atrioesophageal fistula following ablation procedures for atrial fibrillation: systematic review of case reports. Open Heart. 2015;2(1):e000257. doi:10.1136/openhrt-2015-000257.Orosey M, Garg L, Agrawal S, et al. Atrioesophageal fistula following radiofrequency catheter ablation of atrial fibrillation. Rev Cardiovasc Med. 2017;18:115-22. doi:10.3909/ricm0883.Orosey M, Garg L, Agrawal S, et al. Atrioesophageal fistula following radiofrequency catheter ablation of atrial fibrillation. Rev Cardiovasc Med. 2017;18:115-22. doi:10.3909/ricm0883.Han HC, Ha FJ, Sanders P, et al. Atrioesophageal fistula: clinical presentation, procedural characteristics, diagnostic investigations, and treatment outcomes. Circ Arrhythm Electrophysiol. 2017;10:pii:e005579. doi:10.1161/circep.117.005579.Han HC, Ha FJ, Sanders P, et al. Atrioesophageal fistula: clinical presentation, procedural characteristics, diagnostic investigations, and treatment outcomes. Circ Arrhythm Electrophysiol. 2017;10:pii:e005579. doi:10.1161/circep.117.005579.Maradey-Romero C, Fass R. New therapies for non-cardiac chest pain. Curr Gastroenterol Rep. 2014;16:390. doi:10.1007/s11894-014-0390-4.Maradey-Romero C, Fass R. New therapies for non-cardiac chest pain. Curr Gastroenterol Rep. 2014;16:390. doi:10.1007/s11894-014-0390-4.Nakaji G, Fujihara M, Fukata M, et al. Influence of common cardiac drugs on gastroesophageal reflux disease: multicenter questionnaire survey. Int J Clin Pharmacol Ther. 2011;49:555-62. doi:10.5414/CP201558.Nakaji G, Fujihara M, Fukata M, et al. Influence of common cardiac drugs on gastroesophageal reflux disease: multicenter questionnaire survey. Int J Clin Pharmacol Ther. 2011;49:555-62. doi:10.5414/CP201558.Bytzer P, Connolly SJ, Yang S, et al. Analysis of upper gastrointestinal adverse events among patients given dabigatran in the RE-LY trial. Clin Gastroenterol Hepatol. 2013;11:246-52. doi:10.1016/j.cgh.2012.10.021.Bytzer P, Connolly SJ, Yang S, et al. Analysis of upper gastrointestinal adverse events among patients given dabigatran in the RE-LY trial. Clin Gastroenterol Hepatol. 2013;11:246-52. doi:10.1016/j.cgh.2012.10.021.Toya Y, Nakamura S, Tomita K, et al. Dabigatrn-induced esophagitis: the prevalence and endoscopic characteristics. J Gastroenterol Hepatol.2016;31:610-4. doi:10.1111/jgh.13024.Toya Y, Nakamura S, Tomita K, et al. Dabigatrn-induced esophagitis: the prevalence and endoscopic characteristics. J Gastroenterol Hepatol.2016;31:610-4. doi:10.1111/jgh.13024.Новикова Н. А., Воловченко А. Н., Олдаковский В. И. Гастроэнтерологические осложнения антикоагулянтной терапии у больных с неклапанной фибрилляцией предсердий. Экспериментальная и клиническая гастроэнтерология. 2015;118(6):57-63.Novikova NA, Volovchenko AN, Aldakovsky VI. Gastroenterological complications of anticoagulant therapy in patients with non-valvular atrial fibrillation. Experimental and clinical gastroenterology. 2015;118(6):57-63. (In Russ.)

The authors declare that there are no conflicts of interest present.