russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2015-10-92-98russjcardiol-323Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWГЕНЕТИЧЕСКИЕ ОСНОВЫ РЕЗИСТЕНТНОСТИ К КЛОПИДОГРЕЛЮ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫGENETICS OF CLOPIDOGREL RESISTANCE: RECENT DATAМирзаевК. Б.MirzaevK. B.

Интерн кафедры клинической фармакологии и терапии

karin05doc@yandex.ruСычевД. А.SychevD. A.

Доктор медицинских наук, профессор, зав. кафедрой клинической фармакологии и терапии

karin05doc@yandex.ruАндреевД. А.AndreevD. A.

Доктор медицинских наук, профессор кафедры неотложной кардиологии

karin05doc@yandex.ruРоссийская медицинская академия последипломного образования, МоскваРоссияRussian Medical Academy of Postgraduate Education, MoscowRussian FederationПервый Московский государственный медицинский университет имени И. М. Сеченова, МоскваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation2015281020150109298Copyright © Мирзаев К.Б., Сычев Д.А., Андреев Д.А., 20152015Мирзаев К.Б., Сычев Д.А., Андреев Д.А.Mirzaev K.B., Sychev D.A., Andreev D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/323

Антиагрегантная терапия занимает одну из ведущих позиций в фармакотерапии пациентов с поражением коронарных, церебральных и периферических артерий. Стандартом лечения больных с острым коронарным синдромом является двойная антиагрегантная терапия: ацетилсалициловая кислота в сочетании с блокатором P2Y12-рецепторов. Некоторые генетические особенности пациентов могут приводить к формированию резистентности к антитромбоцитарной терапии с развитием тромботических осложнений. Данный обзор литературы призван акцентировать внимание на ряде фармакогенетических особенностей пациентов, приводящих к резистентности антиагрегантной терапии клопидогрелем. 

Antiplatelet therapy is one of the most importance in therapy of patients with injured coronary, cerebral and peripheral arteries. The standard of acute coronary syndrome patients treatment is double antiplatelet therapy: acetylsalicylic acid with P2Y12receptor blocker. Some distinguished genetic specifics might lead to the development of resistance to antiplatelet therapy with further thrombotic complications. Current review focuses on the pharmacogenetic specifics of patients than lead clopidogrel resistance. 

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The authors declare that there are no conflicts of interest present.