russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2018-5-68-73russjcardiol-2822Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON THE ISSUEФИКСИРОВАННЫЕ КОМБИНАЦИИ В ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ: НОВЫЕ ВОЗМОЖНОСТИFIXED COMBINATIONS IN ARTERIAL HYPERTENSION TREATMENT: NOVEL OPPORTUNITIESПодзолковВ. И.PodzolkovV. I.

Профессор, доктор медицинских наук, зав. кафедрой факультетской терапии № 2 лечебного факультета

ТарзимановаА. И.TarzimanovaA. I.

Кандидат медицинских наук, доцент кафедры факультетской терапии № 2 лечебного факультета

tarzimanova@mail.ruФГАОУ ВО Первый МГМУ им. И. М. Сеченова (Сеченовский Университет)РоссияФГАОУ ВО Первый МГМУ им. И. М. Сеченова (Сеченовский Университет)РоссияI. M. Sechenov First Moscow State Medical University of the Ministry of HealthRussian Federation201802062018056873Copyright © Подзолков В.И., Тарзиманова А.И., 20182018Подзолков В.И., Тарзиманова А.И.Podzolkov V.I., Tarzimanova A.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/2822

Артериальная гипертензия (АГ) остается одним из самых распространенных в мире сердечно-сосудистых заболеваний и важнейшим фактором риска развития инфаркта миокарда и мозгового инсульта. Монотерапия АГ эффективна не более чем у половины пациентов даже с умеренным повышением артериальным давлением. Комбинированная антигипертензивная терапия в наибольшей степени решает проблему воздействия на патогенетические механизмы АГ Перспективным является появление нового препарата, представляющего собой фиксированную комбинацию телмисартана и гидрохлоротиазида. Сочетание этих компонентов имеет аддитивный антигипертензивный эффект, снижающий артериальное давление в большей степени, чем каждый компонент самостоятельно и обладает значительным органопротективным потенциалом, что позволяет назначать эту комбинацию для лечения широкого круга пациентов

Arterial hypertension (AH) remains one of the most prevalent cardiovascular disorder in the world, as one of the main risk factors of myocardial infarction and stroke development. Monotherapy of AH is effective in no more than one half of patients even with moderate increase of blood pressure. Combinational antihypertension treatment does influence pathogenetic mechanisms of AH being an optimal solution. It is worthful to apply a fixed combination of telmisartan and hydrochlorothiazide. Such combination provides additional antihypertensive effect with more significant decrease of blood pressure than for the components separately. Also it is protective for organs and tissues that makes it to prescribe such combination to a broad range of patients.

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The authors declare that there are no conflicts of interest present.