russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2018-3-65-70russjcardiol-2753Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWВЛИЯНИЕ ИНГИБИРОВАНИЯ ХА ФАКТОРА С ПОМОЩЬЮ РИВАРОКСАБАНА НА ПРОГРЕССИРОВАНИЕ, РИСК ОСЛОЖНЕНИЙ И СМЕРТНОСТЬ ПРИ ИБСINHIBITION OF THE FACTOR XA (WITH RIVAROXABAN) SLOW DOWN PROGRESSION, PREVENTS COMPLICATION AND DECREASE MORTALITY IN CORONARY HEART DISEASEХирмановВ. Н.KhirmanovV. N.

Санкт-Петербург.

Saint-Petersburg.

vkhirmanov@mail.ruФГБУ Всероссийский центр экстренной и радиационной медицины им. А. М. Никифорова МЧС России.РоссияA. M. Nikiforov Russian Center of Urgent and Radiation Medicine of the EMERCOM.Russian Federation201810042018036570Copyright © Хирманов В.Н., 20182018Хирманов В.Н.Khirmanov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/2753

Представлен обзор новых научных данных, главным образом результатов крупных клинических испытаний, свидетельствующих о клинической эффективности и безопасности применения ривароксабана — антикоагулянта, селективного блокатора фактора Xa — в лечении больных острыми и хроническими формами ишемической болезни сердца. Объясняются механизмы воздействия препарата на процессы атеротромбоза, особенности дозирования ривароксабана и его применения в комбинации с другими антитромботическими средствами в разных клинических ситуациях.

A review presented, of the novel scientific data, mostly the results of large clinical trials, witnessing on clinical efficacy and safety of rivaroxaban — the anticoagulant, selective blocker of Xa factor — in treatment of acute and chronic coronary heart disease. The mechanisms explained, of the drug influence on atherothrombosis, especially the specifics of dosages and its combination with other antithrombotic drugs in various clinical situations.

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The authors declare that there are no conflicts of interest present.