russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2018-4-111-116russjcardiol-2656Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWКАТЕСТАТИН КАК НОВЫЙ МАРКЕР СЕРДЕЧНО-СОСУДИСТОГО РИСКА У БОЛЬНЫХ  ГИПЕРТОНИЧЕСКОЙ БОЛЕЗНЬЮCATESTATIN AS A NOVEL MARKER OF CARDIOVASCULAR RISK IN SYSTEMIC HYPERTENSIONhttps://orcid.org/0000-0001-6824-3963ГубареваЕ. Ю.GubarevaE. Yu.

 очный аспирант кафедры внутренних болезней.

Самара.

Samara.

ekaterina.ju.gubareva@gmail.comКрюковН. Н.KryukovN. N.

профессор зав. кафедрой внутренних болезней, заслуженный деятель науки РФ.

Самара.

 

Samara.

nicolai.kryukov@yandex.ruГубареваИ. В.GubarevaI. V.

д. м.н., доцент кафедры внутренних болезней.

Samara.

irigub@rambler.ruФГБОУ ВО Самарский государственный медицинский университет Минздрава России.РоссияSamara State Medical University of the Ministry of Health.Russian Federation20180905201804111116Copyright © Губарева Е.Ю., Крюков Н.Н., Губарева И.В., 20182018Губарева Е.Ю., Крюков Н.Н., Губарева И.В.Gubareva E.Y., Kryukov N.N., Gubareva I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/2656

Обзор ключевых исследований по изучению антигипертензивного, вазодилататорного, ангиогенного и анти-апоптотического действия катестатина — пептида, образующегося в результате взаимодействия эндогенных протеаз с С-концом хромогранина А. Плазменные уровни катестатина обратно коррелируют с фенотипом артериальной гипертензии, особенно на ранних стадиях развития гипертонической болезни. Обсуждается патогенетическая роль катестатина в развитии гипертонической болезни и его возможное использование в качестве маркера стратификации сердечно-сосудистого риска.

Review of the key studies on antihypertensive, vasodilatatory, angiogenic and antiapoptotic action of catestatin — a peptide resulting from endogenic protease interaction with chromogranin А. Plasma levels of catestatin correlate negatively with the hypertension phenotype. Pathogenetic role is discussed for catestatin in development of essential hypertension and its possible influence as a marker of cardiovascular risk stratification.

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The authors declare that there are no conflicts of interest present.