russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2017-8-102-106russjcardiol-2512Research ArticleКЛИНИКА И ФАРМАКОТЕРАПИЯGUIDELINES FOR THE PRACTITIONERВОЗМОЖНОСТИ КОМБИНАЦИИ АЗИЛСАРТАНА МЕДОКСОМИЛА И ХЛОРТАЛИДОНА: МОЖНО ЛИ БОРОТЬСЯ С АРТЕРИАЛЬНОЙ ГИПЕРТОНИЕЙ И ОЖИРЕНИЕМ ОДНОВРЕМЕННО?COMBINATION OF AZILSARTAN MEDOXOMIL AND CHLORTHALIDONE: IS IT POSSIBLE TO FIGHT SYSTEMIC HYPERTENSION AND OBESITY TOGETHER?ВасюкЮ. А.VasyukYu. A.

д. м.н., профессор, зав. кафедрой клинической функциональной диагностики

https://orcid.org/0000-0001-6188-4610ШупенинаЕ. Ю.ShupeninaE. Yu.

к. м.н., доцент кафедры клинической функциональной диагностики

eshupenina@mail.ruНестероваЕ. А.NesterovaE. A.

к. м.н., доцент кафедры клинической функциональной диагностики

ГолубковаЭ. И.GolubkovaE. I.

аспирант кафедры клинической функциональной диагностики

НесветовВ. В.NesvetovV. V.

к. м.н., ассистент кафедры клинической функциональной диагностики

ФГБОУ ВО Московский государственный медико-стоматологический университет им. А. И. ЕвдокимоваA. I. Evdokimov Moscow State University of Medicine and Dentistry (MSUMD)20170710201708102106Copyright © Васюк Ю.А., Шупенина Е.Ю., Нестерова Е.А., Голубкова Э.И., Несветов В.В., 20172017Васюк Ю.А., Шупенина Е.Ю., Нестерова Е.А., Голубкова Э.И., Несветов В.В.Vasyuk Y.A., Shupenina E.Y., Nesterova E.A., Golubkova E.I., Nesvetov V.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/2512

Артериальная гипертония (АГ) и ожирение являются основными факторами риска развития хронических неинфекционных заболеваний. Жировая ткань является не только хранилищем энергетических запасов, но и активным эндокринным органом, синтезирующим биологически активные соединения, которые способствуют развитию АГ. Пациенты с АГ и ожирением относятся к группе высокого сердечно-сосудистого риска и нуждаются в эффективной комбинированной антигипертензивной терапии. Одним из таких препаратов является фиксированная комбинация азилсартана медоксомила и хлорталидона, чья эффективность и безопасность подтверждена многочисленными исследованиями. В нашем клиническом примере показано положительное действие Эдарби Кло на офисное и суточное АД, основные параметры жесткости аорты и структурно-функциональное состояние миокарда в покое и при физической нагрузке у пациента с АГ и ожирением.

Arterial hypertension (AH) and obesity are the main risk factors of chronic noncommunicable diseases. Adipous tissue is not only a depot for energetic compounds, but is an active endocrine organ synthetizing biologically active substances that facilitate development of AH. Patients with AH and obesity are in the high cardiovascular risk group and demand effective combination antihypertension therapy. One of such drugs is the fixed combination of azilsartan medoxomil and chlorthalidone, which safety and efficacy are confirmed by various trials. Our clinical case demonstrates positive action of Edarbi Сlo on office and 24-hour blood pressure (BP), main parameters of aorta stiffness and structural and functional condition of myocardium at rest, as in exertion in patient with AH and obesity.

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The authors declare that there are no conflicts of interest present.