russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2017-10-140-146russjcardiol-2382Research ArticleОБЗОРЫREVIEWСТРУКТУРНАЯ ВАРИАБЕЛЬНОСТЬ ГЕНОМА ЛЕЙКОЦИТОВ И КЛЕТОК АРТЕРИЙ ПРИ АТЕРОСКЛЕРОЗЕ У ЧЕЛОВЕКАSTRUCTURAL VARIABLITY OF LEUCOCYTE GENOME AND ARTERIAL CELLS IN HUMAN ATHEROSCLEROSISСлепцовА. А.SleptsovА. A.

Слепцов Алексей Анатольевич — младший научный сотрудник лаборатории популяционной генетики.

alexei.sleptcov@medgenetics.ruhttps://orcid.org/0000-0002-0673-4094НазаренкоМ. С.NazarenkoM. S.

Назаренко Мария  Сергеевна — кандидат медицинских наук, руководитель лаборатории популяционной генетики.

SPIN-код 8137-3739

maria.nazarenko@medgenetics.ruПузыревВ. П.PuzyrevV. P.

Пузырев Валерий Павлович — доктор медицинских наук, академик РАМН, профессор, научный руководитель, научный руководитель

p.valery@medgenetics.ruНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наукРоссияSRI of Medical Genetics, Tomsk National Research Center of RASRussian FederationНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук; ФГБНУ Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний; ФГБОУ ВПО Сибирский государственный медицинский университет” Минздрава РоссииРоссияSRI of Medical Genetics, Tomsk National Research Center of RAS; SRI of Complex Issues of Cardiovascular Diseases; Siberian State Medical University (SSMU)Russian FederationНаучно-исследовательский институт медицинской генетики, Томский национальный исследовательский медицинский центр Российской академии наук; ФГБОУ ВПО Сибирский государственный медицинский университет” Минздрава РоссииРоссияSRI of Medical Genetics, Tomsk National Research Center of RAS; Siberian State Medical University (SSMU)Russian Federation201725112017010140146Copyright © Слепцов А.А., Назаренко М.С., Пузырев В.П., 20172017Слепцов А.А., Назаренко М.С., Пузырев В.П.Sleptsov А.A., Nazarenko M.S., Puzyrev V.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/2382

В обзоре рассмотрены существующие представления о структурной изменчивости генома соматических клеток как компоненты, связанной с атеросклерозом. Приведены результаты собственного исследования о спектре вариаций числа копий участков ДНК в лейкоцитах периферической крови и клетках артерий при их атеросклеротическом поражении у человека. Обозначены перспективы исследования структурной вариабельности генома соматических клеток для понимания патогенетики многофакторных заболеваний человека.

The review is focused on current views on the structural variation of genome of somatic cells as components related to atherosclerosis. The original data presented on the variation spectrum of DNA areas copies in peripheral blood leucocytes and arterial cells in human atherosclerosis. The future directions sketched for the research on somatic cells genome variation with the aim for pathogenetics of multifactorial diseases.

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The authors declare that there are no conflicts of interest present.