<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2017-5-85-90</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-2320</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФИЦИАЛЬНАЯ ИНФОРМАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFORMATION</subject></subj-group></article-categories><title-group><article-title>РЕЗУЛЬТАТЫ КЛИНИЧЕСКОГО ИССЛЕДОВАНИЯ FOURIER. НОВЫЕ ВОЗМОЖНОСТИ ЛЕЧЕНИЯ ПАЦИЕНТОВ ОЧЕНЬ ВЫСОКОГО СЕРДЕЧНО-СОСУДИСТОГО РИСКА</article-title><trans-title-group xml:lang="en"><trans-title>RESULTS OF THE CLINICAL TRIAL FOURIER. NEW OPPORTUNITIES FOR TREATMENT OF VERY HIGH CARDIOVASCULAR RISK PATIENTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Совет</surname><given-names>Экспертов</given-names></name><name name-style="western" xml:lang="en"><surname>Board</surname><given-names>Advisory</given-names></name></name-alternatives><bio xml:lang="ru"><p>Президиум экспертного совета: Бойцов С.А. (Москва), Карпов Ю. А. (Москва), Ежов М. В. (Москва).</p><p>Эксперты: Алекян Б. Г. (Москва), Ахмеджанов Н.М. (Москва), Бажан С. С. (Новосибирск), Бубнова М. Г. (Москва), Воевода М. И. (Новосибирск), Гуревич В.С. (Санкт-Петербург), Ершова А.И. (Москва), Кашталап В.В. (Кемерово), Коновалов Г. А. (Москва), Константинов В. О. (Санкт-Петербург), Кухарчук В. В. (Москва), Мешков А. Н. (Москва), Сергиенко И. В. (Москва), Шальнова С. А. (Москва). </p></bio><bio xml:lang="en"><p>Chairs of the Advisory Board: Boytsov S. А. (Moscow), Karpov Yu. А. (Moscow), Ezhov М. V. (Moscow).</p><p>Experts: Alekian B. G. (Moscow), Akhmedzhanov N. М. (Moscow), Bazhan S. S. (Novosibirsk), Bubnova M. G. (Moscow), Voevoda М. I. (Novosibirsk), Gurevich V. S. (Saint-Petersburg), Ershova А. I. (Moscow), Kashtalap V. V. (Kemerovo), Konovalov G. А. (Moscow), Konstantinov V. О. (Saint-Petersburg), Kukharchuk V.V. (Moscow), Meshkov А.N. (Moscow), Sergienko I.V. (Moscow), Shalnova S. А. (Moscow). </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российское кардиологическое общество (РКО); &#13;
Национальное общество по изучению атеросклероза (НОА); Российское общество кардиосоматической реабилитации и вторичной профилактики (РосОКР)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Board of Russian Society of Cardiology (RSC); &#13;
Russian National Atherosclerosis Society (RNAS); &#13;
Russian Society of Cardiosomatic Rehabilitation and Secondary Prevention (RSCRSP)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>09</day><month>06</month><year>2017</year></pub-date><volume>0</volume><issue>5</issue><fpage>85</fpage><lpage>90</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Совет Э., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Совет Э.</copyright-holder><copyright-holder xml:lang="en">Board A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/2320">https://russjcardiol.elpub.ru/jour/article/view/2320</self-uri><abstract><p>Совет Экспертов Российского кардиологического общества (РКО), Национального общества по изучению атеросклероза (НОА), Российского общества кардиосоматической реабилитации и вторичной профилактики (РосОКР) </p></abstract><trans-abstract xml:lang="en"><p>Advisory Board of Russian Society of Cardiology (RSC), Russian National Atherosclerosis Society (RNAS), Russian Society of Cardiosomatic Rehabilitation and Secondary Prevention (RSCRSP) </p></trans-abstract><kwd-group xml:lang="ru"><kwd>FOURIER</kwd><kwd>эволокумаб</kwd><kwd>гиполипидемическая терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>FOURIER</kwd><kwd>evolocumab</kwd><kwd>hypolipidemic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kotseva K, Wood D, De Bacquer D, et al. EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016; 23 (6): 636-48.</mixed-citation><mixed-citation xml:lang="en">Kotseva K, Wood D, De Bacquer D, et al. EUROASPIRE IV: A European Society of Cardiology survey on the lifestyle, risk factor and therapeutic management of coronary patients from 24 European countries. Eur J Prev Cardiol. 2016; 23 (6): 636-48.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Oganov RG, Kukharchuk VV, Arutyunov GP, et al. Persistent violations of lipid spectrum in patients with dyslipidemia receiving statins in clinical practice in the Russian Federation (the Russian part of the study DYSIS). Cardiovascular Therapy and Prevention. 2012; 11 (4): 70-8. Russian (Оганов Р. Г., Кухарчук В. В., Арутюнов Г. П. и др. Сохраняющиеся нарушения показателей липидного спектра у пациентов с дислипидемией, получающих статины, в реальной клинической практике в российской федерации (российская часть исследования DYSIS). Кардиоваскулярная терапия и профилактика. 2012; 11 (4): 70-8).</mixed-citation><mixed-citation xml:lang="en">Oganov RG, Kukharchuk VV, Arutyunov GP, et al. Persistent violations of lipid spectrum in patients with dyslipidemia receiving statins in clinical practice in the Russian Federation (the Russian part of the study DYSIS). Cardiovascular Therapy and Prevention. 2012; 11 (4): 70-8. Russian (Оганов Р. Г., Кухарчук В. В., Арутюнов Г. П. и др. Сохраняющиеся нарушения показателей липидного спектра у пациентов с дислипидемией, получающих статины, в реальной клинической практике в российской федерации (российская часть исследования DYSIS). Кардиоваскулярная терапия и профилактика. 2012; 11 (4): 70-8).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cholesterol Treatment Trialists’ (CTT) Collaboration et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010; 376: 1670-81.</mixed-citation><mixed-citation xml:lang="en">Cholesterol Treatment Trialists’ (CTT) Collaboration et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010; 376: 1670-81.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J Lipid Res. 2009; 50 (suppl): S15-S27.</mixed-citation><mixed-citation xml:lang="en">Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer’s bottle to Scap’s MELADL. J Lipid Res. 2009; 50 (suppl): S15-S27.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Chan JC, Piper DE, Cao Q, et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A. 2009;106: 9820-5.</mixed-citation><mixed-citation xml:lang="en">Chan JC, Piper DE, Cao Q, et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A. 2009;106: 9820-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderateor high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA. 2014; 311(18): 1870-82.</mixed-citation><mixed-citation xml:lang="en">Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderateor high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA. 2014; 311(18): 1870-82.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Koren MJ, Sabatine MS, Giugliano RP, et al. Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study. JAMA Cardiol. 2017. doi: 10.1001/jamacardio.2017.0747. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Koren MJ, Sabatine MS, Giugliano RP, et al. Long-term Low-Density Lipoprotein Cholesterol-Lowering Efficacy, Persistence, and Safety of Evolocumab in Treatment of Hypercholesterolemia: Results Up to 4 Years From the Open-Label OSLER-1 Extension Study. JAMA Cardiol. 2017. doi: 10.1001/jamacardio.2017.0747. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA. 2016; 316 (22): 2373-84.</mixed-citation><mixed-citation xml:lang="en">Nicholls SJ, Puri R, Anderson T, et al. Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial. JAMA. 2016; 316 (22): 2373-84.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and Clinical Outcomes in Pati ents with Cardiovascular Disease. N Engl J Med. 2017. doi: 10.1056/NEJMoa1615664. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and Clinical Outcomes in Pati ents with Cardiovascular Disease. N Engl J Med. 2017. doi: 10.1056/NEJMoa1615664. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Giugliano RP, Mach F, Zavitz Kv, et al. EBBINGHAUS:-A Cognitive Study of Patients Enrolled in the FOURIER Trial. Presented at the American College of Cardiology, Washington, 2017.</mixed-citation><mixed-citation xml:lang="en">Giugliano RP, Mach F, Zavitz Kv, et al. EBBINGHAUS:-A Cognitive Study of Patients Enrolled in the FOURIER Trial. Presented at the American College of Cardiology, Washington, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Catapano AL, Graham I, De Backer G et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. Eur Heart J. 2016; 37 (39): 2999-3058.</mixed-citation><mixed-citation xml:lang="en">Catapano AL, Graham I, De Backer G et al. 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias. Eur Heart J. 2016; 37 (39): 2999-3058.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Landmesser U, John Chapman M, Farnier M, et al. European Society of Cardiology/ European Atherosclerosis Society Task Force consensus statement on proprotein conve rtase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk. Eur Heart J. 2016. pii: ehw480. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Landmesser U, John Chapman M, Farnier M, et al. European Society of Cardiology/ European Atherosclerosis Society Task Force consensus statement on proprotein conve rtase subtilisin/kexin type 9 inhibitors: practical guidance for use in patients at very high cardiovascular risk. Eur Heart J. 2016. pii: ehw480. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 1; 36 (17): 1012-22.</mixed-citation><mixed-citation xml:lang="en">Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact on statin therapy—European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 1; 36 (17): 1012-22.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med 2015; 372: 2387-97.</mixed-citation><mixed-citation xml:lang="en">Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes. N Engl J Med 2015; 372: 2387-97.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Suárez C, Zeymer U, Limbourg T, et al. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010 Aug; 15 (4): 259-65.</mixed-citation><mixed-citation xml:lang="en">Suárez C, Zeymer U, Limbourg T, et al. Influence of polyvascular disease on cardiovascular event rates. Insights from the REACH Registry. Vasc Med. 2010 Aug; 15 (4): 259-65.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Bhatt DL, Eagle KA, Ohman EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010; 304 (12): 1350-7.</mixed-citation><mixed-citation xml:lang="en">Bhatt DL, Eagle KA, Ohman EM, et al. Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA. 2010; 304 (12): 1350-7.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Sokolov AA, Aleksandrova OYu, Kashtalap VV, et al. Methodical recommendations on organization of medical aid to patients with hereditary atherogenic disorders of the lipid metabolism in subjects of the Russian Federation. Atherosclerosis and dyslipidemia 2016; 4, 25: 14-20. Russian (Соколов А. А., Александрова О. Ю., Кашталап В. В. и др. Методические рекомендации по организации медицинской помощи больным с наследственными атерогенными нарушениями липидного обмена в субъектах РФ. Атеросклероз и дислипидемии 2016; 4, 25: 14-20).</mixed-citation><mixed-citation xml:lang="en">Sokolov AA, Aleksandrova OYu, Kashtalap VV, et al. Methodical recommendations on organization of medical aid to patients with hereditary atherogenic disorders of the lipid metabolism in subjects of the Russian Federation. Atherosclerosis and dyslipidemia 2016; 4, 25: 14-20. Russian (Соколов А. А., Александрова О. Ю., Кашталап В. В. и др. Методические рекомендации по организации медицинской помощи больным с наследственными атерогенными нарушениями липидного обмена в субъектах РФ. Атеросклероз и дислипидемии 2016; 4, 25: 14-20).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
