<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1860</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ВОЗРАСТНЫЕ РАЗЛИЧИЯ ДИНАМИКИ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ, СОСТОЯНИЯ РЕНИН-АЛЬДОСТЕРОНОВОЙ СИСТЕМЫ И ЛИПИДНОГО СПЕКТРА КРОВИ ПРИ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИИ ВСЛЕДСТВИЕ ТИРЕОТОКСИКОЗА</article-title><trans-title-group xml:lang="en"><trans-title>THE AGES DIFFERENCES IN BLOOD PRESSURE DYNAMICS, RENIN-ALDOSTERON SYSTEM STATE AND LIPID PROFILE IN PATIENTS WITH ARTERIAL HYPERTENSION AND THYREOTOXYCOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джанашия</surname><given-names>П. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhanashiya</surname><given-names>P. H.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии ФУВ</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Селиванова</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Selivanova</surname><given-names>G. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии ФУВ</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Российский государственный медицинский университет, Москва<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2003</year></pub-date><pub-date pub-type="epub"><day>28</day><month>12</month><year>2003</year></pub-date><volume>0</volume><issue>6</issue><fpage>16</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Джанашия П.Х., Селиванова Г.Б., 2003</copyright-statement><copyright-year>2003</copyright-year><copyright-holder xml:lang="ru">Джанашия П.Х., Селиванова Г.Б.</copyright-holder><copyright-holder xml:lang="en">Dzhanashiya P.H., Selivanova G.B.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1860">https://russjcardiol.elpub.ru/jour/article/view/1860</self-uri><abstract><p>Исследование посвящено изучению возрастных различий динамики артериального давления, состояния ренин-альдостероновой системы и липидного спектра крови у лиц с артериальной гипертензией вследствие тиреотоксикоза. Показано, что среди пожилых пациентов преобладают лица с артериальной гипертензией 2 степени, отмечаются более высокие значения индекса времени гипертензии, вариабельности, величины и скорости утреннего повышения систолического АД, пульсового давления, по данным СМАД, что свидетельствует о повышенном риске сердечно-сосудистых осложнений. Концентрации ренина и альдостерона крови находятся в норме и более низки у пожилых. Уровень кортизола крови у молодых и пожилых пациентов с тиреотоксикозом находится в норме и не различается в зависимости от возраста и степени тяжести артериальной гипертензии. Характер различий в липидном спектре крови выражается в более высоких значениях общего холестерина и триглицеридов у пожилых.</p></abstract><trans-abstract xml:lang="en"><p>There was research about the ages differences in blood pressure dynamics, renin-aldosteron system state and lipid profile in patients with arterial hypertension and thyreotoxicosis. It was find, that the old patients have arterial hypertension 2 degree. It was high value of an index time of hypertension, variability, the mornings rise and speed of systolic blood pressure about blood pressure monitoring. These all means a high risk of cardio-vascular complications. The old patients renin and aldosteron concentrations are normal and low. The thyreotoxicosis young and old patients blood Cortisol concentration are normal and have not different of arterial hypertension degrees. Its no dependents from patients ages. The difference character of blood lipid specter of old patients cholesterol and triglycerides are high.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>тиреотоксикоз</kwd><kwd>суточное мониторирование ад</kwd><kwd>ренин</kwd><kwd>альдостерон</kwd><kwd>кортизол</kwd><kwd>липидный профиль</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>cortisol</kwd><kwd>lipid profile</kwd><kwd>thyreotoxicosis</kwd><kwd>renin-aldoseron system</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И. Артериальная гипертензия -фактор риска сердечно-сосудистых заболеваний.//Русский медицинский журнал. 2002. Т. 10, № 19. C. 862-865.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И. Артериальная гипертензия -фактор риска сердечно-сосудистых заболеваний.//Русский медицинский журнал. 2002. Т. 10, № 19. C. 862-865.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Старкова Н.Т.//Клиническая эндокринология. М.: Медицина, 1991. C. 511.</mixed-citation><mixed-citation xml:lang="en">Старкова Н.Т.//Клиническая эндокринология. М.: Медицина, 1991. C. 511.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Abrams J.J., Grundy S.M., Ginsberg H. Metabolism of plasma triglycerides in hypothyroidism and hyperthyroidism in man//J. lipid research. 1981. Vol. 22. P. 307-322.</mixed-citation><mixed-citation xml:lang="en">Abrams J.J., Grundy S.M., Ginsberg H. Metabolism of plasma triglycerides in hypothyroidism and hyperthyroidism in man//J. lipid research. 1981. Vol. 22. P. 307-322.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Abrams J.J., Grundy S.M. Cholesterol metabolism in hypothyroidism and hyperthyroidism in man//J. lipid research. 1981. Vol. 22. P. 323-338.</mixed-citation><mixed-citation xml:lang="en">Abrams J.J., Grundy S.M. Cholesterol metabolism in hypothyroidism and hyperthyroidism in man//J. lipid research. 1981. Vol. 22. P. 323-338.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cachefo A., Boucher Ph., Vidon С. et al.//J. Clin. endocrinol. and metab. 2001. Vol. 86, N 11. h. 5355-5357.</mixed-citation><mixed-citation xml:lang="en">Cachefo A., Boucher Ph., Vidon С. et al.//J. Clin. endocrinol. and metab. 2001. Vol. 86, N 11. h. 5355-5357.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">de Bruin T.W., van Barlingen H., van Linde-Sibenius M. et al. Lipoprotein (a) and apolipoprotein В plasma concentration in hypothyroid, euthyroid and hyperthyroid subjects//J. clin. Endocrinol. metabol. 1993. Vol. 176. P. 121-126.</mixed-citation><mixed-citation xml:lang="en">de Bruin T.W., van Barlingen H., van Linde-Sibenius M. et al. Lipoprotein (a) and apolipoprotein В plasma concentration in hypothyroid, euthyroid and hyperthyroid subjects//J. clin. Endocrinol. metabol. 1993. Vol. 176. P. 121-126.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Diekman M.J., Anghelescu N., Endert E. et al. Changes in plasma low-density lipoprotein and high-density lipoprotein cholesterol in hypo-and hyperthyroid patients are related to changes in free thyroxine, not to polymorphism in LDL receptor on cholesterol ester transfer protein genes//J. Clin. Endocrinol. Metabol. 2000. Vol. 85. P. 1857-1862.</mixed-citation><mixed-citation xml:lang="en">Diekman M.J., Anghelescu N., Endert E. et al. Changes in plasma low-density lipoprotein and high-density lipoprotein cholesterol in hypo-and hyperthyroid patients are related to changes in free thyroxine, not to polymorphism in LDL receptor on cholesterol ester transfer protein genes//J. Clin. Endocrinol. Metabol. 2000. Vol. 85. P. 1857-1862.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Faber J., Wiinberg N., Schifter H. et al. Hemodynamic changes following treatment of subclinical and overt hyperthyroidism//Eur. J. endocrinol. 2001. Vol. 145. Iss. 4. N 10. p/391-396.</mixed-citation><mixed-citation xml:lang="en">Faber J., Wiinberg N., Schifter H. et al. Hemodynamic changes following treatment of subclinical and overt hyperthyroidism//Eur. J. endocrinol. 2001. Vol. 145. Iss. 4. N 10. p/391-396.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuyama K., Ichiki Т., Takeda K. et al. Downregulation of vascular angiotensin II type I receptor by thyroid hormone//Hypertension. 2003. Vol. 41. P. 598.</mixed-citation><mixed-citation xml:lang="en">Fukuyama K., Ichiki Т., Takeda K. et al. Downregulation of vascular angiotensin II type I receptor by thyroid hormone//Hypertension. 2003. Vol. 41. P. 598.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Glynn R.J., Chae C.U., Guralnik J.M. et al. Pulse pressure and mortality in older people//Arch. Intern. Med. 2000. Vol. 160. P. 2765-2772.</mixed-citation><mixed-citation xml:lang="en">Glynn R.J., Chae C.U., Guralnik J.M. et al. Pulse pressure and mortality in older people//Arch. Intern. Med. 2000. Vol. 160. P. 2765-2772.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hellstrom L., Wahrenberg H., Reynisdottir S. Catecholamine-induced adipocite lypolisis in human hyperthyroidism//J. clin. Endocrinol. metabol. 1997. Vol. 82, N 1. P. 159-166.</mixed-citation><mixed-citation xml:lang="en">Hellstrom L., Wahrenberg H., Reynisdottir S. Catecholamine-induced adipocite lypolisis in human hyperthyroidism//J. clin. Endocrinol. metabol. 1997. Vol. 82, N 1. P. 159-166.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Hoshide S., Kario K., Hoshide Y. et al. Association between non-dipping of nocturnal blood pressure decreased and cardiovascular target organ damaged in strictly selected community-dwelling normotensives//Hypertension. 2003. Vol. 16. Iss. 6, № 6. P. 434-438.</mixed-citation><mixed-citation xml:lang="en">Hoshide S., Kario K., Hoshide Y. et al. Association between non-dipping of nocturnal blood pressure decreased and cardiovascular target organ damaged in strictly selected community-dwelling normotensives//Hypertension. 2003. Vol. 16. Iss. 6, № 6. P. 434-438.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kobori H., Hayashi M., Saruta T. Thyroid hormone stimulates rennin gene expression through the thyroid hormone response element//Hypertension. 2001. Vol. 37. P. 99.</mixed-citation><mixed-citation xml:lang="en">Kobori H., Hayashi M., Saruta T. Thyroid hormone stimulates rennin gene expression through the thyroid hormone response element//Hypertension. 2001. Vol. 37. P. 99.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Marinakis A.G., Vyssoulis G.P., Mechaelides A.P. et al. Impact of abnormal blood pressure fall on vascular function//Hypertension. 2003. Vol. 16. Iss. 3, N 3. P. 209-213.</mixed-citation><mixed-citation xml:lang="en">Marinakis A.G., Vyssoulis G.P., Mechaelides A.P. et al. Impact of abnormal blood pressure fall on vascular function//Hypertension. 2003. Vol. 16. Iss. 3, N 3. P. 209-213.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Miura K., Dyer A.R., Greenland Ph. et al. Pulse pressure compared with other blood pressure indexes in the prediction of 25-year cardiovascular and all-cause mortality rates//Hypertension. 2001. Vol. 38. P. 232.</mixed-citation><mixed-citation xml:lang="en">Miura K., Dyer A.R., Greenland Ph. et al. Pulse pressure compared with other blood pressure indexes in the prediction of 25-year cardiovascular and all-cause mortality rates//Hypertension. 2001. Vol. 38. P. 232.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ohkubo T., Hozawa A., Imai Y. Prognostic impact of 24-hour mean pressure and pulse pressure on stroke//Circulation. 2001. Vol. 104. P. 160.</mixed-citation><mixed-citation xml:lang="en">Ohkubo T., Hozawa A., Imai Y. Prognostic impact of 24-hour mean pressure and pulse pressure on stroke//Circulation. 2001. Vol. 104. P. 160.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Petretta M., Bonaduce D., Spinelli L. et al. Cardiovascular hemodynamics and cardiac autonomic control in patients with subclinical and overt hyperthyroidism//Eur. J. endocrinol. 2001. Vol 145. Iss. 6. P. 691-696/</mixed-citation><mixed-citation xml:lang="en">Petretta M., Bonaduce D., Spinelli L. et al. Cardiovascular hemodynamics and cardiac autonomic control in patients with subclinical and overt hyperthyroidism//Eur. J. endocrinol. 2001. Vol 145. Iss. 6. P. 691-696/</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Scheuer D.A., Bechtlod A.G. Glucocorticoids potentiate central action of angiotensin to increase arterial pressure//Am. J. physiol. Regul. Integr. Сотр. Physiol. 2001. Vol. 280. Iss. 6. N 6. P. R1719-R1726.</mixed-citation><mixed-citation xml:lang="en">Scheuer D.A., Bechtlod A.G. Glucocorticoids potentiate central action of angiotensin to increase arterial pressure//Am. J. physiol. Regul. Integr. Сотр. Physiol. 2001. Vol. 280. Iss. 6. N 6. P. R1719-R1726.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Schaaf L., Pohl Т., Schmidt R. et al. Screening for thyroid disorders in a working population//Clin. Investig. 1993. Vol. 71. P. 126-131.</mixed-citation><mixed-citation xml:lang="en">Schaaf L., Pohl Т., Schmidt R. et al. Screening for thyroid disorders in a working population//Clin. Investig. 1993. Vol. 71. P. 126-131.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Schillaci G., Verdecchia P., Benemio G. et al. Blood pressure rise and ischemic stroke//Lancet. 1995. Vol. 346. P. 1366-7.</mixed-citation><mixed-citation xml:lang="en">Schillaci G., Verdecchia P., Benemio G. et al. Blood pressure rise and ischemic stroke//Lancet. 1995. Vol. 346. P. 1366-7.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Tsatsoulis A., Johnson E.O. Kalogera S.H. et al. The effect of thyrotoxicosis on adrenocortical reserve//Eur. J. endocrinol. 2000. Vol. 142. Iss. 3. p. 231-235.</mixed-citation><mixed-citation xml:lang="en">Tsatsoulis A., Johnson E.O. Kalogera S.H. et al. The effect of thyrotoxicosis on adrenocortical reserve//Eur. J. endocrinol. 2000. Vol. 142. Iss. 3. p. 231-235.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Van Bortel L.M., Struijker-Boudier H.A., Safar M.E. et al. Pulse pressure, arterial stiffness and drug treatment of hypertension//Hypertension. 2001. Vol. 38. P. 914.</mixed-citation><mixed-citation xml:lang="en">Van Bortel L.M., Struijker-Boudier H.A., Safar M.E. et al. Pulse pressure, arterial stiffness and drug treatment of hypertension//Hypertension. 2001. Vol. 38. P. 914.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">White W.B., Schulman P., McCabe E.J. et al. Average daily blood pressure, not office blood pressure, determines cardiac function in patients with hypertension//Am. J. Med. Ass. 1989. Vol. 261. P. 873.</mixed-citation><mixed-citation xml:lang="en">White W.B., Schulman P., McCabe E.J. et al. Average daily blood pressure, not office blood pressure, determines cardiac function in patients with hypertension//Am. J. Med. Ass. 1989. Vol. 261. P. 873.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
