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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1843</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>РЕПЕРФУЗИЯ У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА</article-title><trans-title-group xml:lang="en"><trans-title>Reperfusion in acute myocardial infarction patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гордеев</surname><given-names>И. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Gordeev</surname><given-names>I. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ильенко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ilyenko</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клыков</surname><given-names>Л. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Klykov</surname><given-names>L. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Люсов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lusov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шайдюк</surname><given-names>О. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shaydyuk</surname><given-names>O. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра госпитальной терапии №1</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Российский государственный медицинский университет</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2006</year></pub-date><volume>0</volume><issue>3</issue><fpage>71</fpage><lpage>75</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гордеев И.Г., Ильенко И.В., Клыков Л.Л., Люсов В.А., Лебедева А.Ю., Шайдюк О.Ю., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Гордеев И.Г., Ильенко И.В., Клыков Л.Л., Люсов В.А., Лебедева А.Ю., Шайдюк О.Ю.</copyright-holder><copyright-holder xml:lang="en">Gordeev I.G., Ilyenko I.V., Klykov L.L., Lusov V.A., Lebedeva A.Y., Shaydyuk O.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1843">https://russjcardiol.elpub.ru/jour/article/view/1843</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Руда М.Я. Что нужно знать практическому врачу о тромболитической терапии при инфаркте миокарда?//Сердце: журнал для практикующих врачей. 2002. Т. 1, № 1. C. 9-12.</mixed-citation><mixed-citation xml:lang="en">Руда М.Я. Что нужно знать практическому врачу о тромболитической терапии при инфаркте миокарда?//Сердце: журнал для практикующих врачей. 2002. Т. 1, № 1. C. 9-12.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Fibrinolytic Therapy Trialists (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major mortality results from all randomized trials of more than 1000 patients. Lancet 1994; 343: 311-322.</mixed-citation><mixed-citation xml:lang="en">Fibrinolytic Therapy Trialists (FTT) Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major mortality results from all randomized trials of more than 1000 patients. Lancet 1994; 343: 311-322.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Максименко А.В., Тищенко Е.Г. Комбинированный тромболизис -новое направление исследование активаторов плазминогена третьего поколения//Вопросы биологической медицины и фармакологической химии. 2000. № 1. С. 1-10.</mixed-citation><mixed-citation xml:lang="en">Максименко А.В., Тищенко Е.Г. Комбинированный тромболизис -новое направление исследование активаторов плазминогена третьего поколения//Вопросы биологической медицины и фармакологической химии. 2000. № 1. С. 1-10.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Clinical Cardiology. Bolus Fibrinolytic Therapy in Acute Myocardial infartion. JAMA 2001; 286(4).</mixed-citation><mixed-citation xml:lang="en">Clinical Cardiology. Bolus Fibrinolytic Therapy in Acute Myocardial infartion. JAMA 2001; 286(4).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств. 2002. С. 735.</mixed-citation><mixed-citation xml:lang="en">Метелица В.И. Справочник по клинической фармакологии сердечно-сосудистых лекарственных средств. 2002. С. 735.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">А.А. Куприна, А.А. Упницкий, Ю.Б. Белоусов. Алтеплаза: клиническая фармакология, перспективы применения при остром инфаркте миокарда, фармакоэкономические аспекты//Фарматека. 2004. № 19-20(96). С. 17-20.</mixed-citation><mixed-citation xml:lang="en">А.А. Куприна, А.А. Упницкий, Ю.Б. Белоусов. Алтеплаза: клиническая фармакология, перспективы применения при остром инфаркте миокарда, фармакоэкономические аспекты//Фарматека. 2004. № 19-20(96). С. 17-20.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sabatine M.S., Cannon С.Р., Gibson C.M., et al. Addition of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial Infartion with ST-Segment Elevation. N. Engl. J. Med. 2005 Mar; 10: 352.</mixed-citation><mixed-citation xml:lang="en">Sabatine M.S., Cannon С.Р., Gibson C.M., et al. Addition of Clopidogrel to Aspirin and Fibrinolytic Therapy for Myocardial Infartion with ST-Segment Elevation. N. Engl. J. Med. 2005 Mar; 10: 352.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Mehilli J., et al. Gender and Myocardial Salvage After Reperfusion Treatment in Acute Myocardial Infarction. J. Am. Coll. Cardiol. 2005; 45: 828-31.</mixed-citation><mixed-citation xml:lang="en">Mehilli J., et al. Gender and Myocardial Salvage After Reperfusion Treatment in Acute Myocardial Infarction. J. Am. Coll. Cardiol. 2005; 45: 828-31.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gerschlic A.H., Stephens-Lloyd A.S., Hughes S., et al. Rescue Angioplasty after Failed Thrombolytic Therapy for Acute Myocardial Infartion. N. Engl. J. Med. 2005; 353: 2758-68.</mixed-citation><mixed-citation xml:lang="en">Gerschlic A.H., Stephens-Lloyd A.S., Hughes S., et al. Rescue Angioplasty after Failed Thrombolytic Therapy for Acute Myocardial Infartion. N. Engl. J. Med. 2005; 353: 2758-68.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">De Wood M.A., Spores J., Notske R.N., et al. Prevalence of total coronary artery occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980; 303: 897.</mixed-citation><mixed-citation xml:lang="en">De Wood M.A., Spores J., Notske R.N., et al. Prevalence of total coronary artery occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980; 303: 897.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected myocardial infarction: ISIS-2. Lancet 1988; 2: 349-60.</mixed-citation><mixed-citation xml:lang="en">ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected myocardial infarction: ISIS-2. Lancet 1988; 2: 349-60.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">The GUSTO Angiographic Investigators. The effect of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after myocardial infarction. N. Engl. J. Med. 1993; 329: 1615-22.</mixed-citation><mixed-citation xml:lang="en">The GUSTO Angiographic Investigators. The effect of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after myocardial infarction. N. Engl. J. Med. 1993; 329: 1615-22.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Чернецов В.А., Господаренко А.Л. Предикторы возникновения рецидивирующих расстройств кровообращения у больных крупноочаговым инфарктом миокарда после тромболитической терапии//Российский кардиологический журнал. 1999. № 6. С. 11-14.</mixed-citation><mixed-citation xml:lang="en">Чернецов В.А., Господаренко А.Л. Предикторы возникновения рецидивирующих расстройств кровообращения у больных крупноочаговым инфарктом миокарда после тромболитической терапии//Российский кардиологический журнал. 1999. № 6. С. 11-14.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Andrews J. ST-segment recovery adds to the assessment of TIMI 2 and 3 flow in predicting infarct wall motion after thrombolytic therapy. Circulation 2000; 101: 2138, AHA.</mixed-citation><mixed-citation xml:lang="en">Andrews J. ST-segment recovery adds to the assessment of TIMI 2 and 3 flow in predicting infarct wall motion after thrombolytic therapy. Circulation 2000; 101: 2138, AHA.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Braunwald E. Heart disease. London. WB Saunders Company; 1997. pр. 1184-1289.</mixed-citation><mixed-citation xml:lang="en">Braunwald E. Heart disease. London. WB Saunders Company; 1997. pр. 1184-1289.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Le May M.R., Wells G.A., Labinaz M., et al. Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study). J. Am. Coll. Cardiol. 2005; 46(3): 417-24.</mixed-citation><mixed-citation xml:lang="en">Le May M.R., Wells G.A., Labinaz M., et al. Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study). J. Am. Coll. Cardiol. 2005; 46(3): 417-24.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Schomig A., Mehili J., Antonicci D., et al. Mechanical Reperfusion in Patients Wth Acute Myocardial Infartion Presenting More Than 12 Hours From Symptom Onset. A Randomized Controlled Trial. JAMA 2005; 293: 2865-2872.</mixed-citation><mixed-citation xml:lang="en">Schomig A., Mehili J., Antonicci D., et al. Mechanical Reperfusion in Patients Wth Acute Myocardial Infartion Presenting More Than 12 Hours From Symptom Onset. A Randomized Controlled Trial. JAMA 2005; 293: 2865-2872.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandes-Avilas F., Alonso J.J., Castro-Beiras A., et al. Routine invasive strategy within 24 hours of thrombolysis versus ischami-aquided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. Lancet 2004; 364: 1045-53.</mixed-citation><mixed-citation xml:lang="en">Fernandes-Avilas F., Alonso J.J., Castro-Beiras A., et al. Routine invasive strategy within 24 hours of thrombolysis versus ischami-aquided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-1): a randomised controlled trial. Lancet 2004; 364: 1045-53.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yellon D.M., Baxter G.F. Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality. Heart 2000; 83: 381-387.</mixed-citation><mixed-citation xml:lang="en">Yellon D.M., Baxter G.F. Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality. Heart 2000; 83: 381-387.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kloner R.A. Does reperfusion injury exist in human? J. Am. Coll. Cardiol. 1993; 21: 537.</mixed-citation><mixed-citation xml:lang="en">Kloner R.A. Does reperfusion injury exist in human? J. Am. Coll. Cardiol. 1993; 21: 537.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Jennings R.B., Schaper J., Hill M.L., et al. Effect of reperfusion late in the phase of reversible ischaemic injury: Changes in cell volume, electrolytes, metabolites, and ultrastructure. Circ Res 1985; 56: 262</mixed-citation><mixed-citation xml:lang="en">Jennings R.B., Schaper J., Hill M.L., et al. Effect of reperfusion late in the phase of reversible ischaemic injury: Changes in cell volume, electrolytes, metabolites, and ultrastructure. Circ Res 1985; 56: 262</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Braunwald E., Kloner R.A. Myocardial reperfusion: A double-edged sword? J. Clin. Invest. 1985; 76: 1715.</mixed-citation><mixed-citation xml:lang="en">Braunwald E., Kloner R.A. Myocardial reperfusion: A double-edged sword? J. Clin. Invest. 1985; 76: 1715.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ito H., Iwakura K., Oh H., et al. Temporary changes in myocardial perfusion in patients with reperfused anterior myocardial infarction. Circulation 1995; 91: 656-62.</mixed-citation><mixed-citation xml:lang="en">Ito H., Iwakura K., Oh H., et al. Temporary changes in myocardial perfusion in patients with reperfused anterior myocardial infarction. Circulation 1995; 91: 656-62.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ito H., Tomooka T., Sakai N., et al. Lack of myocardial perfusion immediately after successful thtombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation 1992; 85: 1699-705.</mixed-citation><mixed-citation xml:lang="en">Ito H., Tomooka T., Sakai N., et al. Lack of myocardial perfusion immediately after successful thtombolysis: a predictor of poor recovery of left ventricular function in anterior myocardial infarction. Circulation 1992; 85: 1699-705.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Solomon S.D., Ridker P.M., Antman E.M. Ventricular arrhythmias in trials of thrombolytic therapy for acute myocardial infarction: A meta-analysis. Circulation 1993; 88: 2575.</mixed-citation><mixed-citation xml:lang="en">Solomon S.D., Ridker P.M., Antman E.M. Ventricular arrhythmias in trials of thrombolytic therapy for acute myocardial infarction: A meta-analysis. Circulation 1993; 88: 2575.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Vera Z., Pride H.P., Zipes D.P. Reperfusion arrhythmias: Role of early afterdepolarisations studied by monophasic action potential recordings in the infarct canine heart during autonomically denervated and stimulated sites. J. Cardiovasc. Electrophysiol. 1995; 6: 532.</mixed-citation><mixed-citation xml:lang="en">Vera Z., Pride H.P., Zipes D.P. Reperfusion arrhythmias: Role of early afterdepolarisations studied by monophasic action potential recordings in the infarct canine heart during autonomically denervated and stimulated sites. J. Cardiovasc. Electrophysiol. 1995; 6: 532.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Дядык А.И., Багрий А.Э. Приколота О.А. и др. Желудочковые нарушения ритма при остром инфаркте миокарда. Часть 1. Эпидемиология, клиническая характеристика и прогностическая значимость. // Украинский кардиол. журн. 2001. № 3. C. 92-98.</mixed-citation><mixed-citation xml:lang="en">Дядык А.И., Багрий А.Э. Приколота О.А. и др. Желудочковые нарушения ритма при остром инфаркте миокарда. Часть 1. Эпидемиология, клиническая характеристика и прогностическая значимость. // Украинский кардиол. журн. 2001. № 3. C. 92-98.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Chiladacis J., Karapanos G., Davlouros P. Significant of R-on T-phenomenon in early ventricular tachyarrhythmia susceptibility after acute myocardial infarction in the thrombolytic era. Am. J. Cardiology. 2000. Vol. 85, N 3. P. 289-293.</mixed-citation><mixed-citation xml:lang="en">Chiladacis J., Karapanos G., Davlouros P. Significant of R-on T-phenomenon in early ventricular tachyarrhythmia susceptibility after acute myocardial infarction in the thrombolytic era. Am. J. Cardiology. 2000. Vol. 85, N 3. P. 289-293.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari R., Cecconi C., Curello S., Cargnoni A., et al. Occurrence of oxidative stress during myocardial reperfusion. Mol. Cell. Biochem. 1992; 111: 61-9.</mixed-citation><mixed-citation xml:lang="en">Ferrari R., Cecconi C., Curello S., Cargnoni A., et al. Occurrence of oxidative stress during myocardial reperfusion. Mol. Cell. Biochem. 1992; 111: 61-9.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrari R., Niccoli L., Vision O., Harris P. Myocardial metabolism during intracoronary thrombolysis. Int. J. Cardiol. 1987; 15: 293-9.</mixed-citation><mixed-citation xml:lang="en">Ferrari R., Niccoli L., Vision O., Harris P. Myocardial metabolism during intracoronary thrombolysis. Int. J. Cardiol. 1987; 15: 293-9.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Jennings R.B., Hawkins H.K., Lowe J.E., Hill M.L., Klotman S., Reimer K.A. Relation between high-energy phosphate and lethal injury in myocardial ischemia in the dog. Am. J. Pathol., 1978; 92: 187-214.</mixed-citation><mixed-citation xml:lang="en">Jennings R.B., Hawkins H.K., Lowe J.E., Hill M.L., Klotman S., Reimer K.A. Relation between high-energy phosphate and lethal injury in myocardial ischemia in the dog. Am. J. Pathol., 1978; 92: 187-214.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rao V., Ivanov J., Weisel R.D., et al. Lactate release during reperfusion predicts low cardiac output syndrome after coronary bypass surgery. Ann. Thorac. Surg. 2001; 71: 1925-1930.</mixed-citation><mixed-citation xml:lang="en">Rao V., Ivanov J., Weisel R.D., et al. Lactate release during reperfusion predicts low cardiac output syndrome after coronary bypass surgery. Ann. Thorac. Surg. 2001; 71: 1925-1930.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Rao V., Merante F., Weisel R.D., et al. Insulin stimulates pyruvate dehydrogenase and protects human ventricular cardiomyocytes from simulated ischaemia. J. Thorac. Cardiovasc. Surg. 1998; 116: 485-494.</mixed-citation><mixed-citation xml:lang="en">Rao V., Merante F., Weisel R.D., et al. Insulin stimulates pyruvate dehydrogenase and protects human ventricular cardiomyocytes from simulated ischaemia. J. Thorac. Cardiovasc. Surg. 1998; 116: 485-494.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Bolli R., Jeroudi M.O., Patel B.S., et al. Direct evidence that oxygen-derived free radicals contribute to post-ischaemic myocardial dysfunction in the intact dog. Proc. Nat. Acad. Sci. USA. 1989; 86: 4695-4699.</mixed-citation><mixed-citation xml:lang="en">Bolli R., Jeroudi M.O., Patel B.S., et al. Direct evidence that oxygen-derived free radicals contribute to post-ischaemic myocardial dysfunction in the intact dog. Proc. Nat. Acad. Sci. USA. 1989; 86: 4695-4699.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Coronary endotelial dysfunction after iscemiaand reperfusion and its prevention by iscemic preconditioning/P. Pagliaro, A. Chiribiri, D. Mancardi e.a. Ital. Heart. J. 2003. Vol. 4, N 6. P. 383-394.</mixed-citation><mixed-citation xml:lang="en">Coronary endotelial dysfunction after iscemiaand reperfusion and its prevention by iscemic preconditioning/P. Pagliaro, A. Chiribiri, D. Mancardi e.a. Ital. Heart. J. 2003. Vol. 4, N 6. P. 383-394.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Steg P.G., Grollier G., Gallay P., et al. A randomized double-blind trial of trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction. Evidence for improved myocardial reperfusion from ST-segment analysis. Eur. Heart. J. 1998; 19: 365 (abstract).</mixed-citation><mixed-citation xml:lang="en">Steg P.G., Grollier G., Gallay P., et al. A randomized double-blind trial of trimetazidine as adjunctive therapy to primary PTCA for acute myocardial infarction. Evidence for improved myocardial reperfusion from ST-segment analysis. Eur. Heart. J. 1998; 19: 365 (abstract).</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Gao W.D., Atar D., Liu Y., et al. Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circ. Res. 1997; 80: 393-399.</mixed-citation><mixed-citation xml:lang="en">Gao W.D., Atar D., Liu Y., et al. Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circ. Res. 1997; 80: 393-399.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Gao W.D., Liu Y., Mellgren R., et al. Intrinsic myofilament alterations underlying the decreased contractility of stunned myocardium: a consequence of Ca2+-dependent proteolysis? Circ. Res. 1996; 78: 455-465.</mixed-citation><mixed-citation xml:lang="en">Gao W.D., Liu Y., Mellgren R., et al. Intrinsic myofilament alterations underlying the decreased contractility of stunned myocardium: a consequence of Ca2+-dependent proteolysis? Circ. Res. 1996; 78: 455-465.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Przyklenk K. Parmacological treatment of the stunned myocardium: the concepts and the challenges. Coron. Artery. Dis. 2001; 12: 363-369.</mixed-citation><mixed-citation xml:lang="en">Przyklenk K. Parmacological treatment of the stunned myocardium: the concepts and the challenges. Coron. Artery. Dis. 2001; 12: 363-369.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Vallance P., Chan N. Endotelial Function and nitric oxide: clinical relevance. Heart. 2001. Vol. 85, N 3. P. 342-350.</mixed-citation><mixed-citation xml:lang="en">Vallance P., Chan N. Endotelial Function and nitric oxide: clinical relevance. Heart. 2001. Vol. 85, N 3. P. 342-350.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Granger D.N. Ischaemia-reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 1999; 6: 167-178.</mixed-citation><mixed-citation xml:lang="en">Granger D.N. Ischaemia-reperfusion: mechanisms of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 1999; 6: 167-178.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Pfeffer M.A. Left ventricular remodeling after acute myocardial infarction. Ann. Rev. Med. 1995; 46: 455.</mixed-citation><mixed-citation xml:lang="en">Pfeffer M.A. Left ventricular remodeling after acute myocardial infarction. Ann. Rev. Med. 1995; 46: 455.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Klootwijk P. Noninvasive assessment of reperfusion and re-occlusion after thrombolysis in acute myocardial infarction. Am. J. Cardiol. 1993; 72: 75G-84G.</mixed-citation><mixed-citation xml:lang="en">Klootwijk P. Noninvasive assessment of reperfusion and re-occlusion after thrombolysis in acute myocardial infarction. Am. J. Cardiol. 1993; 72: 75G-84G.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Амосова Е.Н. Метаболическая терапия повреждения миокарда, обусловленного ишемией, новый подход к лечению ишемической болезни сердца и сердечной недостаточности. // Украинский кард. журн. 2000. № 4. C. 85-92.</mixed-citation><mixed-citation xml:lang="en">Амосова Е.Н. Метаболическая терапия повреждения миокарда, обусловленного ишемией, новый подход к лечению ишемической болезни сердца и сердечной недостаточности. // Украинский кард. журн. 2000. № 4. C. 85-92.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Б.В. Дубовик, А.А. Жданов, Д.И. Романовский. Сравнительная кардиоцитопротекторная эффективность аргинина гидрохлорида и аргинина сукцината при ишемическо-реперфузионном поражении миокарда у крыс//Бел. мед. журн. 2005. 4 (14). С. 12-16.</mixed-citation><mixed-citation xml:lang="en">Б.В. Дубовик, А.А. Жданов, Д.И. Романовский. Сравнительная кардиоцитопротекторная эффективность аргинина гидрохлорида и аргинина сукцината при ишемическо-реперфузионном поражении миокарда у крыс//Бел. мед. журн. 2005. 4 (14). С. 12-16.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Lopaschuk G.D. Optimizing cardiac energy metabolism: a new approach to treating ischaemic heart disease//Eur. Heart. J. 1999; 1 (suppl O): 032-039.</mixed-citation><mixed-citation xml:lang="en">Lopaschuk G.D. Optimizing cardiac energy metabolism: a new approach to treating ischaemic heart disease//Eur. Heart. J. 1999; 1 (suppl O): 032-039.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Lopaschuk G.D., Kozak R. Trimetazidine inhibits fatty acids oxidation in the heart//J. Mol. Cell. Cardiol. 1998; 30: A112.</mixed-citation><mixed-citation xml:lang="en">Lopaschuk G.D., Kozak R. Trimetazidine inhibits fatty acids oxidation in the heart//J. Mol. Cell. Cardiol. 1998; 30: A112.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">European Heart Journal (1997) 18, suppl F, F2-F10.</mixed-citation><mixed-citation xml:lang="en">European Heart Journal (1997) 18, suppl F, F2-F10.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
