russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLCrussjcardiol-1774Research ArticleКЛИНИКА И ФАРМАКОТЕРАПИЯGUIDELINES FOR THE PRACTITIONERНОВЫЕ ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ ДИПИРИДАМОЛА В ЛЕЧЕНИИ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦАNEW PERSPECTIVES OF DIPYRIDAMOL USAGE IN TREATMENT OF CORONARY HEART DISEASEБузиашвилиЮ. И.BuziashviliY. I.МацкеплишвилиС. Т.MatskeplishviliS. T.АсымбековаЭ. У.AsymbekovaE. U.ХапийИ. Х.HapiyI. H.БурдулиТ. В.BurduliT. V.ЩербаковаО. С.SherbakovaO. S.БувальцевВ. И.BuvaltsevV. I.Научный центр сердечно-сосудистой хирургии имени А.Н. БакулеваRussian Federation200328082003046771Copyright © Бузиашвили Ю.И., Мацкеплишвили С.Т., Асымбекова Э.У., Хапий И.Х., Бурдули Т.В., Щербакова О.С., Бувальцев В.И., 20032003Бузиашвили Ю.И., Мацкеплишвили С.Т., Асымбекова Э.У., Хапий И.Х., Бурдули Т.В., Щербакова О.С., Бувальцев В.И.Buziashvili Y.I., Matskeplishvili S.T., Asymbekova E.U., Hapiy I.H., Burduli T.V., Sherbakova O.S., Buvaltsev V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/1774

Существует большое количество пациентов с ишемической болезнью сердца, которым не показаны методы реваскуляризации миокарда. Добавление дипиридамола к традиционной антиангинальной терапии способствует улучшению клинической картины заболевания и уменьшению функционального класса стенокардии у больных ИБС. При использовании дипиридамола в течение 3 месяцев отмечается увеличение порога толерантности к физической нагрузке, увеличение времени выполнения нагрузки, уменьшение зон асинергии по данным стресс-ЭхоКГ на высоте нагрузки, что позволяет косвенно судить о возможности ангиогенеза в гипоперфузированных областях миокарда, находящихся в зоне стенозированной коронарной артерии.

There is a great number of coronary patients to whom traditional methods of myocardium revascularization are not indicated. Addition of dipyridamol to traditional antianginal treatment promotes improvement of clinical features of the disease and decreased functional class of angina in coronary patients. The usage of dipyridamol for 3 months was accompanied by increased physical stress tolerance threshold, increased time of physical stress, decreased asynergy areas on echo ate peak stress, suggesting possible angiogenesis in myocardium hypoperfusion areas in the region of stenotic coronary artery.

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The authors declare that there are no conflicts of interest present.