<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2017-7-125-131</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1551</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МНЕНИЕ ПО ПРОБЛЕМЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPINION ON THE ISSUE</subject></subj-group></article-categories><title-group><article-title>СРАВНИТЕЛЬНЫЕ РЕЗУЛЬТАТЫ ВНУТРИСЕРДЕЧНОГО ЭЛЕКТРОФИЗИОЛОГИЧЕСКОГО ИССЛЕДОВАНИЯ У БОЛЬНЫХ С ТИПИЧНЫМ ТРЕПЕТАНИЕМ ПРЕДСЕРДИЙ И ФИБРИЛЛЯЦИЕЙ ПРЕДСЕРДИЙ</article-title><trans-title-group xml:lang="en"><trans-title>COMPARISON RESULTS OF THE INTRACARDIAC ELECTROPHYSIOLOGICAL STUDY IN PATIENTS WITH TYPICAL ATRIAL FLUTTER AND FIBRILLATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новиков</surname><given-names>П. С</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>P. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новиков Петр Сергеевич — аспирант отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца (7-е к/о)</p><p> </p></bio><bio xml:lang="en"/><email xlink:type="simple">cardionov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Певзнер</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pevzner</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Певзнер Александр Викторович — доктор медицинских наук, руководитель лаборатории интервенционных методов диагностики и лечения нарушений ритма, проводимости сердца и синкопальных состояний</p></bio><bio xml:lang="en"/><email xlink:type="simple">avpevzner@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шлевков</surname><given-names>Н. Б</given-names></name><name name-style="western" xml:lang="en"><surname>Shlevkov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шлевков Николай Борисович — кандидат медицинских наук, старший научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца</p></bio><bio xml:lang="en"/><email xlink:type="simple">nikolay-shlevkov@live.co.uk</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Майков</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Maykov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Майков Евгений Борисович — доктор медицинских наук, старший научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца</p></bio><bio xml:lang="en"/><email xlink:type="simple">evmaykov@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миронов</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Mironov</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миронов Николай Юрьевич — кандидат медицинских наук, младший научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца</p></bio><bio xml:lang="en"/><email xlink:type="simple">hukmup@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколов</surname><given-names>С. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolov</surname><given-names>S. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколов Сергей Федорович — кандидат медицинских наук, ведущий научный сотрудник отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца</p></bio><bio xml:lang="en"/><email xlink:type="simple">sokolov@astrocard-meditek.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голицын</surname><given-names>С. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Golitsyn</surname><given-names>S. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Голицын Сергей Павлович — доктор медицинских наук, профессор, руководитель отдела клинической электрофизиологии и рентгенохирургических методов лечения нарушений ритма сердца</p></bio><bio xml:lang="en"/><email xlink:type="simple">golitsyn@umail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Российский кардиологический научно-производственный комплекс МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Cardiological Research-and-Production Complex of the Ministry of Health</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>23</day><month>08</month><year>2017</year></pub-date><volume>0</volume><issue>7</issue><fpage>125</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новиков П.С., Певзнер А.В., Шлевков Н.Б., Майков Е.Б., Миронов Н.Ю., Соколов С.Ф., Голицын С.П., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Новиков П.С., Певзнер А.В., Шлевков Н.Б., Майков Е.Б., Миронов Н.Ю., Соколов С.Ф., Голицын С.П.</copyright-holder><copyright-holder xml:lang="en">Novikov P.S., Pevzner A.V., Shlevkov A.V., Maykov E.V., Mironov N.Y., Sokolov S.F., Golitsyn S.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1551">https://russjcardiol.elpub.ru/jour/article/view/1551</self-uri><abstract><sec><title>Цель</title><p>Цель. Сравнительное изучение параметров внутрисердечного электрофизиологического исследования (ЭФИ) у больных с типичным трепетанием предсердий (ТТП) и фибрилляцией предсердий (ФП), протекающих в формах изолированных аритмий, а также при их сочетании.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Включено 82 больных (59 (72%) мужчин, средний возраст 55 ± 10 лет), направленных для проведения катетерной аблации по поводу ТТП и ФП. Исходя из анамнеза аритмии, больные разделены на 4 группы: №1 – изолированное ТТП (n=26, 32%), №2 – сочетание ФП и «спонтанного» ТТП (n=27, 33%), №3 – ФП и ТТП, где последнее регистрировалось исключительно в условиях применения антиаритмических препаратов IC и III класса (n=14, 17%), №4 – изолированная ФП (n=15, 18%). Всем пациентам выполнено ЭФИ на фоне синусового ритма в условиях отмены антиаритмической терапии. В ходе ЭФИ определены следующие показатели: длительность Р - волны, время межпредсердного и внутрипредсердного проведения, эффективные рефрактерные периоды (ЭРП) в различных областях предсердий. По результатам ЭФИ проведен сравнительный статистический анализ вышеперечисленных признаков между изучаемыми группами.</p></sec><sec><title>Результаты</title><p>Результаты. Больные с ТТП (группы № 1, 2 и 3) в отличие от пациентов с изолированной ФП (группа №4) характеризовались достоверно большей длительностью Р – волны и удлинением времени межпредсердного проведения. Анализ определения ЭРП показал сходную гетерогенность показателей в различных областях предсердий во всех изучаемых группах: наименьшая величина ЭРП выявлена в латеральной области правого предсердия, наибольшая - в дистальном отделе коронарного синуса. Межгрупповые различия по этим параметрам были статистически не значимы.</p></sec><sec><title>Заключение</title><p>Заключение. Для пациентов с ТТП, протекающим как изолированной форме, так и при сочетании с ФП, характерным является существенное замедление времени межпредсердного проведения импульса, что может объяснять у них склонность к развитию тахиаритмий по механизму макро-reentry.  </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Comparison study of the parameters of intracardiac electrophysiological study (EPS) in patients with the typical atrial flutter (TAF) and atrial fibrillation (AF), of the courses as isolated types of arrhythmia.</p></sec><sec><title>Material and methods</title><p>Material and methods. Totally, 82 patients included (59 (72%) males, mean age 55±10 y.o.), directed for catheter ablation procedure for TAF or AF. Depending on the anamnesis of arrhythmia, patients were selected to 4 groups: 1 — isolated TAF (n=26, 32%), 2 — AF with “spontaneous” TAF (n=27, 33%), 3 — AF and TAF, when the latter had been registered only under treatment by antiarrhythmics of IC and III classes (n=14, 17%), 4 — isolated AF (n=15, 18%). All patients underwent EPS within sinus rhythm and no antiarrhythmic therapy. During EPS the following parameters were defined: P-wave duration, time of interand intra-atrial conduction, effective refractory periods (ERP) in various areas of the atria. By the results of EPS, comparative statistical study performed of the listed parameters in the groups.</p></sec><sec><title>Results</title><p>Results. Patients with TAF (groups 1, 2, 3), in difference with isolated AF (group 4) had significantly longer P-wave and inter-atrial conduction time. Analysis of ERP showed similar heterogeneity of the parameters in different areas of the atria in all studied groups: the lowest ERP is found in the lateral area of the right atrium, the highest — in the distal area of coronary sinus. Intergroup differences by these parameters were non-significant.</p></sec><sec><title>Conclusion</title><p>Conclusion. For TAF patients, as an isolated disorder or with AF, the characteristical is significant prolongation of the inter-atrial conduction time, that might expain tendency to tachiarrhythmias of re-entry genesis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>трепетание предсердий</kwd><kwd>фибрилляция предсердий</kwd><kwd>электрофизиологическое исследование</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial flutter</kwd><kwd>atrial fibrillation</kwd><kwd>electrophysiological study</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ФГБУ РКНПК МЗ РФ</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Granada J, Uribe W, Chyou PH, et al. Incidence and predictors of atrial flutter in the general population. J Am Coll Cardiol 2000; 36: 2242-6.</mixed-citation><mixed-citation xml:lang="en">Granada J, Uribe W, Chyou PH, et al. Incidence and predictors of atrial flutter in the general population. J Am Coll Cardiol 2000; 36: 2242-6.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2016; 37: 2893-962.</mixed-citation><mixed-citation xml:lang="en">Kirchhof P, Benussi S, Kotecha D, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J 2016; 37: 2893-962.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Waldo AL. Atrial flutter. In PJ Podrid, PR Kowey (eds.): Cardiac Arrhythmia: Mechanisms, Diagnosis, and Management. 2nd ed. Baltimore: Williams &amp; Wilkens, 2001: 501-16.</mixed-citation><mixed-citation xml:lang="en">Waldo AL. Atrial flutter. In PJ Podrid, PR Kowey (eds.): Cardiac Arrhythmia: Mechanisms, Diagnosis, and Management. 2nd ed. Baltimore: Williams &amp; Wilkens, 2001: 501-16.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Calkins H, Kuck KH, Cappato R, et al. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012; 14: 528-606.</mixed-citation><mixed-citation xml:lang="en">Calkins H, Kuck KH, Cappato R, et al. 2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012; 14: 528-606.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bertaglia E, Zoppo F, Bonso A, et al. Long-term follow-up of radiofrequency catheter ablation of atrial flutter: clinical course and predictors of atrial fibrillation occurrence. Heart 2004; 90: 59-63.</mixed-citation><mixed-citation xml:lang="en">Bertaglia E, Zoppo F, Bonso A, et al. Long-term follow-up of radiofrequency catheter ablation of atrial flutter: clinical course and predictors of atrial fibrillation occurrence. Heart 2004; 90: 59-63.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ellis K, Wazni O, Marrouche N, et al. Incidence of atrial fibrillation post-cavotricuspid isthmus ablation in patients with typical atrial flutter: left-atrial size as an independent predictor of atrial fibrillation recurrence. J Cardiovasc Electrophysiol 2007; 18: 799-802.</mixed-citation><mixed-citation xml:lang="en">Ellis K, Wazni O, Marrouche N, et al. Incidence of atrial fibrillation post-cavotricuspid isthmus ablation in patients with typical atrial flutter: left-atrial size as an independent predictor of atrial fibrillation recurrence. J Cardiovasc Electrophysiol 2007; 18: 799-802.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Waldo AL, Feld GK. Inter-relationships of atrial fibrillation and atrial flutter: mechanisms and clinical implications. J Am Coll Cardiol 2008; 51: 779-86.</mixed-citation><mixed-citation xml:lang="en">Waldo AL, Feld GK. Inter-relationships of atrial fibrillation and atrial flutter: mechanisms and clinical implications. J Am Coll Cardiol 2008; 51: 779-86.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Huang DT, Monahan KM, Zimetbaum P, et al. Hybrid pharmacologic and ablative therapy: a novel and effective approach for the management of atrial fibrillation. J Cardiovasc Electrophysiol 1998; 9: 462-9.</mixed-citation><mixed-citation xml:lang="en">Huang DT, Monahan KM, Zimetbaum P, et al. Hybrid pharmacologic and ablative therapy: a novel and effective approach for the management of atrial fibrillation. J Cardiovasc Electrophysiol 1998; 9: 462-9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chinitz JS, Gerstenfeld EP, Marchlinski FE, et al. Atrial fibrillation is common after ablation of isolated atrial flutter during long-term follow-up. Heart Rhythm 2007, pp. 1029-33. 10. Novikov PS, Shlevkov NB, Pevzner AV, et al. Incidence and risk factors of atrial fibrillation after cavotricuspid catheter ablation in patients with “isolated” typical atrial flutter. Vestn aritmol 2016; 84: 5-11. Russian (Новиков П.С., Шлевков Н.Б., Певзнер А.В. и др. Частота возникновения и факторы риска развития фибрилляции предсердий после радиочастотной катетерной аблации кавотрикуспидального истмуса у больных с “изолированным” типичным трепетанием предсердий. Вестник аритмологии 2016, 84: 5-11).</mixed-citation><mixed-citation xml:lang="en">Chinitz JS, Gerstenfeld EP, Marchlinski FE, et al. Atrial fibrillation is common after ablation of isolated atrial flutter during long-term follow-up. Heart Rhythm 2007, pp. 1029-33. 10. Novikov PS, Shlevkov NB, Pevzner AV, et al. Incidence and risk factors of atrial fibrillation after cavotricuspid catheter ablation in patients with “isolated” typical atrial flutter. Vestn aritmol 2016; 84: 5-11. Russian (Новиков П.С., Шлевков Н.Б., Певзнер А.В. и др. Частота возникновения и факторы риска развития фибрилляции предсердий после радиочастотной катетерной аблации кавотрикуспидального истмуса у больных с “изолированным” типичным трепетанием предсердий. Вестник аритмологии 2016, 84: 5-11).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Baykan M, Celik S, Erd`l C, et al. Effects of P-wave dispersion on atrial fibrillation in patients with acute anterior wall myocardial infarction. Ann. Noninvasive Electrocardiology. 2003, pp. 101-6.</mixed-citation><mixed-citation xml:lang="en">Baykan M, Celik S, Erd`l C, et al. Effects of P-wave dispersion on atrial fibrillation in patients with acute anterior wall myocardial infarction. Ann. Noninvasive Electrocardiology. 2003, pp. 101-6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Schumacher B, Jung W, Lewalter T, et al. Radiofrequency ablation of atrial flutter due to administration of class IC antiarrhythmic drugs for atrial fibrillation. Am J Cardiol 1999; 83: 710-3.</mixed-citation><mixed-citation xml:lang="en">Schumacher B, Jung W, Lewalter T, et al. Radiofrequency ablation of atrial flutter due to administration of class IC antiarrhythmic drugs for atrial fibrillation. Am J Cardiol 1999; 83: 710-3.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Medi C, Teh AW, Roberts-Thomson K, et al. Right atrial remodeling is more advanced in patients with atrial flutter than with atrial fibrillation. J Cardiovasc Electrophysiol 2012; 23: 1067-72.</mixed-citation><mixed-citation xml:lang="en">Medi C, Teh AW, Roberts-Thomson K, et al. Right atrial remodeling is more advanced in patients with atrial flutter than with atrial fibrillation. J Cardiovasc Electrophysiol 2012; 23: 1067-72.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Simpson RJ Jr, Amara I, Foster JR, et al. Thresholds of refractory periods, and conduction times of the normal and diseased human atrium. Am Heart J 1988; 116: 1080-90.</mixed-citation><mixed-citation xml:lang="en">Simpson RJ Jr, Amara I, Foster JR, et al. Thresholds of refractory periods, and conduction times of the normal and diseased human atrium. Am Heart J 1988; 116: 1080-90.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Kühlkamp V, Haasis R, Seipel L. Atrial vulnerability and electrophysiology determined in patients with and without paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 1992; 15: 71-80.</mixed-citation><mixed-citation xml:lang="en">Kühlkamp V, Haasis R, Seipel L. Atrial vulnerability and electrophysiology determined in patients with and without paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 1992; 15: 71-80.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
