russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2014-11-83-87russjcardiol-155Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWЭНДОТЕЛИНЫ И СЕРДЕЧНО-СОСУДИСТАЯ ПАТОЛОГИЯENDOTHELINES AND CARDIOVASCULAR PATHOLOGYАлиеваА. М.AlievaA. M.

Кандидат медицинских наук, врач-терапевт, отделения неинвазивной аритмологии 6-го терапевтического отделения, врач-терапевт

amisha_alieva@mail.ruЧирковаН. Н.ChirkovaN. N.

6-е терапевтическое отделение, врач-терапевт

amisha_alieva@mail.ruПинчукТ. В.PinchukT. V.

Ассистент кафедры факультетской терапии педиатрического факультета

amisha_alieva@mail.ruАндрееваО. Н.AndreevaO. N.

Кандидат медицинских наук, доцент кафедры факультетской терапии педиатрического факультета

amisha_alieva@mail.ruПивоваровВ. Ю.PivovarovV. Yu.

Кандидат медицинских наук, доцент кафедры факультетской терапии педиатрического факультета

amisha_alieva@mail.ruНаучный центр сердечно-сосудистой хирургии имени А. Н. Бакулева РАМН; Центральная клиническая больница РАН, МоскваРоссияScientific Centre of Cardiovascular Surgery n.a. A. N. Bakulev of RAMS; SBHI Central Clinical Hospital of RAS, MoscowRussian FederationЦентральная клиническая больница РАН, МоскваРоссияCentral Clinical Hospital of RAS, MoscowRussian FederationРоссийский национальный исследовательский медицинский университет имени Н. И. Пирогова, МоскваРоссияRussian National Research Medical University n.a. N. I. Pirogov, MoscowRussian Federation2014281120140118387Copyright © Алиева А.М., Чиркова Н.Н., Пинчук Т.В., Андреева О.Н., Пивоваров В.Ю., 20142014Алиева А.М., Чиркова Н.Н., Пинчук Т.В., Андреева О.Н., Пивоваров В.Ю.Alieva A.M., Chirkova N.N., Pinchuk T.V., Andreeva O.N., Pivovarov V.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/155

Многие исследования последних лет были посвящены изменениям в системе эндотелина, как одному из ключевых звеньев эндотелиальной дисфункции. Активация эндотелиновой системы, маркером которой является повышение уровня эндотелина и его предшественника, наблюдается при многих сердечно-сосудистых заболеваниях. Доказано достоверное повышение уровня эндотелина-1 и Big-эндотелина при атеросклерозе, стенокардии, остром инфаркте миокарда, гипертонической болезни и легочной гипертензии.

Many studies of the last years were concerned the changes in endotheline system as one of the chains in endothelial dysfunction. Activation of endotheline system, which is marked by the increase of endotheline level and its predecessor, is common for many cardiovascular diseases. The significant increase of endotheline-1 and Big-endotheline is shown in atherosclerosis, angina, acute myocardial infarction, hypertensive disease and pulmonary hypertension.

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The authors declare that there are no conflicts of interest present.