russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2014-11-70-75russjcardiol-150Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWРОЛЬ ИНДУЦИРУЕМОГО ГИПОКСИЕЙ ФАКТОРА-1 (HIF-1) В РЕАЛИЗАЦИИ ЦИТОПРОТЕКТИВНОГО ЭФФЕКТА ИШЕМИЧЕСКОГО И ФАРМАКОЛОГИЧЕСКОГО ПОСТКОНДИЦИОНИРОВАНИЯTHE ROLE OF HYPOXIA-INDUCED FACTOR-1 (HIF-1) IN CYTOPROTECTION EFFECT IN ISCHEMIC AND PHARMACOLOGIC POSTCONDITIONINGЩербакН. С.ShcherbakN. S.

Кандидат биологических наук, старший научный сотрудник лаборатории неотложной кардиологии Института сердечно-сосудистых заболеваний

shcherbakns@yandex.ruГалагудзаМ. М.GalagudzaM. M.

Доктор медицинских наук, профессор кафедры патофизиологии, руководитель Института экспериментальной медицины

shcherbakns@yandex.ruШляхтоЕ. В.ShlyakhtoE. V.

Доктор медицинских наук, профессор, академик РАМН, директор ФГБУ, заведующий кафедрой факультетской терапии

shcherbakns@yandex.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова; Федеральный центр сердца, крови и эндокринологии им. В. А. Алмазова, Санкт-ПетербургРоссияThe First Saint-Petersburg State Medical University n.a. Academician I. P. Pavlov; Federal Centre of the Heart, Blood and Endocrinology n.a. V. A. Almazov, Saint-PetersburgRussian Federation2014281120140117075Copyright © Щербак Н.С., Галагудза М.М., Шляхто Е.В., 20142014Щербак Н.С., Галагудза М.М., Шляхто Е.В.Shcherbak N.S., Galagudza M.M., Shlyakhto E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/150

В обзоре проанализированы результаты экспериментальных исследований, направленных на изучение влияния ишемического и фармакологического посткондиционирования печени, головного мозга, миокарда и скелетной мышцы на экспрессию и активность индуцируемого гипоксией фактора-1α (HIF-1α) у различных видов лабораторных животных.

The review concerns on the experimental studies results of the influence of ischemic and pharmacological post conditioning of the liver, brain, myocardium and scelet muscle on the expression and activity of the hypoxia-induced factor-1α (HIF-1α) in various types of lab animals.

посткондиционированиеиндуцируемый гипоксией фактор (HIF)ишемия-реперфузиясердцепеченьголовной мозгpostconditioninghypoxia-induced factor (HIF)ischemia-reperfusionheartliverbrainReferencesShlyakhto EV, Galagudza MM, Syrenskij AV, et al. Ischemic postconditioning infarction: a new way to protect the heart from reperfusion injury. Terapevticheskij arhiv. 2005; 77(5): 77–80. Russian (Шляхто Е. В., Галагудза М. М., Сыренский А. В.и др. Ишемическое посткондиционирование миокарда: новый способ защиты сердца от реперфузионного повреждения. Терапевтический архив. 2005; 77(5): 77-80).Shlyakhto EV, Galagudza MM, Syrenskij AV, et al. Ischemic postconditioning infarction: a new way to protect the heart from reperfusion injury. Terapevticheskij arhiv. 2005; 77(5): 77–80. Russian (Шляхто Е. В., Галагудза М. М., Сыренский А. В.и др. Ишемическое посткондиционирование миокарда: новый способ защиты сердца от реперфузионного повреждения. Терапевтический архив. 2005; 77(5): 77-80).Maslov LN, Mrochek AG, Hanush L, et al. The phenomenon of ischemic postconditioning of the heart. Rossijskij fiziologicheskij zhurnal im. I. M. Sechenova. 2012; 98(8): 943-61. Russian (Маслов Л. Н., Мрочек А. Г., Хануш Л., и соавт. Феномен ишемического посткондиционирования сердца. Российский физиологический журнал им. И. М. Сеченова. 2012; 98(8): 943-61).Maslov LN, Mrochek AG, Hanush L, et al. The phenomenon of ischemic postconditioning of the heart. Rossijskij fiziologicheskij zhurnal im. I. M. Sechenova. 2012; 98(8): 943-61. Russian (Маслов Л. Н., Мрочек А. Г., Хануш Л., и соавт. Феномен ишемического посткондиционирования сердца. Российский физиологический журнал им. И. М. Сеченова. 2012; 98(8): 943-61).de Rougemont O, Lehmann K, Clavien PA. Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver. Liver Transpl. 2009; 15(10): 1172-82. doi: 10.1002/lt.21876.de Rougemont O, Lehmann K, Clavien PA. Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver. Liver Transpl. 2009; 15(10): 1172-82. doi: 10.1002/lt.21876.Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003; 285: 579-88.Zhao ZQ, Corvera JS, Halkos ME, et al. Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2003; 285: 579-88.Huang H, Zhang L, Wang Y, et al. Effect of ischemic post-conditioning on spinal cord ischemic-reperfusion injury in rabbits. Can J Anaesth. 2007; 54: 42-8.Huang H, Zhang L, Wang Y, et al. Effect of ischemic post-conditioning on spinal cord ischemic-reperfusion injury in rabbits. Can J Anaesth. 2007; 54: 42-8.Santos CHM, Gomes OM, Pontes JCDV, et al. The ischemic preconditioning and postconditioning effect on the intestinal mucosa of rats undergoing mesenteric ischemia/ reperfusion process. Acta Cir Bras. 2008; 23: 22-8.Santos CHM, Gomes OM, Pontes JCDV, et al. The ischemic preconditioning and postconditioning effect on the intestinal mucosa of rats undergoing mesenteric ischemia/ reperfusion process. Acta Cir Bras. 2008; 23: 22-8.Zhang WL, Zhao YL, Liu XM, et al. Protective role of mitochondrial K-ATP channel and mitochondrial membrane transport pore in rat kidney ischemic postconditioning. Chin Med J (Engl). 2011; 124(14): 2191-5.Zhang WL, Zhao YL, Liu XM, et al. Protective role of mitochondrial K-ATP channel and mitochondrial membrane transport pore in rat kidney ischemic postconditioning. Chin Med J (Engl). 2011; 124(14): 2191-5.Shcherbak N, Popovetsky M, Galagudza M, et al. The infarct-limiting effect of cerebral ischemic postconditioning in rats depends on the middle cerebral artery branching pattern. Int J Exp Pathol. 2013; 94(1): 34-8.Shcherbak N, Popovetsky M, Galagudza M, et al. The infarct-limiting effect of cerebral ischemic postconditioning in rats depends on the middle cerebral artery branching pattern. Int J Exp Pathol. 2013; 94(1): 34-8.Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995; 92(5): 510-4.Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995; 92(5): 510-4.Loor G, Schumacker PT. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differ. 2008; 15(4): 686-90.Loor G, Schumacker PT. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death Differ. 2008; 15(4): 686-90.Correia SC, Carvalho C, Cardoso S, et al., Mitochondrial preconditioning: a potential neuroprotective strategy. Front Aging Neurosci. 2010; 26(2): 138.Correia SC, Carvalho C, Cardoso S, et al., Mitochondrial preconditioning: a potential neuroprotective strategy. Front Aging Neurosci. 2010; 26(2): 138.Hollmann M, Hartley M, Heinemann S. Ca2+ permeability of KA-AMPAgated glutamate receptor channels depends on subunit composition. Science. 1991; 252(5007): 851-3.Hollmann M, Hartley M, Heinemann S. Ca2+ permeability of KA-AMPAgated glutamate receptor channels depends on subunit composition. Science. 1991; 252(5007): 851-3.Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 of hypoxiainducible factor 1. Genes & Dev. 1998; 12: 149-62.Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O2 of hypoxiainducible factor 1. Genes & Dev. 1998; 12: 149-62.Masson N, Ratcliffe PJ. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. J Cell Sci. 2003; 116(Pt 15): 3041-9.Masson N, Ratcliffe PJ. HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels. J Cell Sci. 2003; 116(Pt 15): 3041-9.Plamondon H, Blondeau N, Heurteaux C, et al. Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and KATP channels. J Cereb Blood Flow Metab. 1999; 19: 1296-308.Plamondon H, Blondeau N, Heurteaux C, et al. Mutually protective actions of kainic acid epileptic preconditioning and sublethal global ischemia on hippocampal neuronal death: involvement of adenosine A1 receptors and KATP channels. J Cereb Blood Flow Metab. 1999; 19: 1296-308.Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003; 9(6): 677-84.Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003; 9(6): 677-84.Tanaka H, Grooms SY, Bennett MV, et al. The AMPAR subunit GluR2: still front and centerstage. Brain Res. 2000; 886(1-2): 190-207.Tanaka H, Grooms SY, Bennett MV, et al. The AMPAR subunit GluR2: still front and centerstage. Brain Res. 2000; 886(1-2): 190-207.Fang LQ, Xu H, Sun Y, et al. Induction of inducible nitric oxide synthase by isoflurane postconditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury. Brain Res. 2012; 1451: 1-9. doi: 10.1016/j.brainres.2012.02.055.Fang LQ, Xu H, Sun Y, et al. Induction of inducible nitric oxide synthase by isoflurane postconditioning via hypoxia inducible factor-1α during tolerance against ischemic neuronal injury. Brain Res. 2012; 1451: 1-9. doi: 10.1016/j.brainres.2012.02.055.Ye Z, Guo Q, Xia P, et al. Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia. Brain Res. 2012; 1463: 63-74. doi: 10.1016/j.brainres.2012.04.050.Ye Z, Guo Q, Xia P, et al. Sevoflurane postconditioning involves an up-regulation of HIF-1α and HO-1 expression via PI3K/Akt pathway in a rat model of focal cerebral ischemia. Brain Res. 2012; 1463: 63-74. doi: 10.1016/j.brainres.2012.04.050.Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J. Neurochem. 1999; 72: 1187-203.Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J. Neurochem. 1999; 72: 1187-203.Stocker R, Yamamoto Y, McDonagh AF, et al. Bilirubin is an antioxidant of possible physiological importance. Science. 1987; 235: 1043-6.Stocker R, Yamamoto Y, McDonagh AF, et al. Bilirubin is an antioxidant of possible physiological importance. Science. 1987; 235: 1043-6.Volti GL, Sacerdoti D, Sangras B, et al. Carbonmonoxide signaling in promoting angiogenesis in human microvessel endothelial cells. Antioxid. Redox Signal. 2005; 7: 704-10.Volti GL, Sacerdoti D, Sangras B, et al. Carbonmonoxide signaling in promoting angiogenesis in human microvessel endothelial cells. Antioxid. Redox Signal. 2005; 7: 704-10.Yang Y, Chen J, Li L, et al. Effect of different mild hypoxia manipulations on kainic acidinduced seizures in the hippocampus of rats. Neurochem Res. 2013; 38(1): 123-32. doi: 10.1007/s11064-012-0899-6.Yang Y, Chen J, Li L, et al. Effect of different mild hypoxia manipulations on kainic acidinduced seizures in the hippocampus of rats. Neurochem Res. 2013; 38(1): 123-32. doi: 10.1007/s11064-012-0899-6.Leconte C, Tixier E, Freret T, et al. Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse. Stroke. 2009; 40(10): 3349-55.Leconte C, Tixier E, Freret T, et al. Delayed hypoxic postconditioning protects against cerebral ischemia in the mouse. Stroke. 2009; 40(10): 3349-55.Lee M, Ryu JK, Piao S, et al. Efficient gene expression system using the RTP801 promoter in the corpus cavernosum of high-cholesterol diet-induced erectile dysfunction rats for gene therapy. J Sex Med. 2008; 5: 1355-64.Lee M, Ryu JK, Piao S, et al. Efficient gene expression system using the RTP801 promoter in the corpus cavernosum of high-cholesterol diet-induced erectile dysfunction rats for gene therapy. J Sex Med. 2008; 5: 1355-64.Zhu XY, Rodriguez-Porcel M, Bentley MD, et al. Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia. Circulation 2004; 109: 2109-15.Zhu XY, Rodriguez-Porcel M, Bentley MD, et al. Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia. Circulation 2004; 109: 2109-15.Zhao H, Wang Y, Wu Y, et al. Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. Acta Biochim Biophys Sin (Shanghai). 20 09; 41(9): 745-53.Zhao H, Wang Y, Wu Y, et al. Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. Acta Biochim Biophys Sin (Shanghai). 20 09; 41(9): 745-53.Knudsen AR, Kannerup AS, Grønbæk H, et al. Effects of ischemic preand postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver. Comp Hepatol. 2011; 10(1): 3. doi: 10.1186/1476-5926-10-3.Knudsen AR, Kannerup AS, Grønbæk H, et al. Effects of ischemic preand postconditioning on HIF-1α, VEGF and TGF-β expression after warm ischemia and reperfusion in the rat liver. Comp Hepatol. 2011; 10(1): 3. doi: 10.1186/1476-5926-10-3.Song X, Zhang N, Xu H, et al. Combined preconditioning and postconditioning provides synergistic protection against liver ischemic reperfusion injury. Int J Biol Sci. 2012; 8(5): 707-18. doi: 10.7150/ijbs.4231.Song X, Zhang N, Xu H, et al. Combined preconditioning and postconditioning provides synergistic protection against liver ischemic reperfusion injury. Int J Biol Sci. 2012; 8(5): 707-18. doi: 10.7150/ijbs.4231.Guo JY, Yang T, Sun XG, et al. Ischemic postconditioning attenuates liver warm ischemiareperfusion injury through Akt-eNOS-NO-HIF pathway. J Biomed Sci. 2011; 18: 79. doi: 10.1186/1423-0127-18-79.Guo JY, Yang T, Sun XG, et al. Ischemic postconditioning attenuates liver warm ischemiareperfusion injury through Akt-eNOS-NO-HIF pathway. J Biomed Sci. 2011; 18: 79. doi: 10.1186/1423-0127-18-79.Yingjia G, Tong Y, Jun L, et al. Rb1 postconditioning attenuates liver warm ischemia– reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 2011; 88: 598-605.Yingjia G, Tong Y, Jun L, et al. Rb1 postconditioning attenuates liver warm ischemia– reperfusion injury through ROS-NO-HIF pathway. Life Sciences. 2011; 88: 598-605.Li F, Sonveaux P, Rabbani ZN, et al. Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell. 2007; 26: 63-74.Li F, Sonveaux P, Rabbani ZN, et al. Regulation of HIF-1alpha stability through S-nitrosylation. Mol Cell. 2007; 26: 63-74.Mateo J, Garcia-Lecea M, Cadenas S, et al. Regulation of hypoxia-inducible factor-1 and independent pathways. Biochem J 2003; 376: 537-44.Mateo J, Garcia-Lecea M, Cadenas S, et al. Regulation of hypoxia-inducible factor-1 and independent pathways. Biochem J 2003; 376: 537-44.Metzen E, Zhou J, Jelkmann W, et al. Nitric oxide impairs normoxic degradation of HIF- 1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell. 2003; 14: 3470-81.Metzen E, Zhou J, Jelkmann W, et al. Nitric oxide impairs normoxic degradation of HIF- 1alpha by inhibition of prolyl hydroxylases. Mol Biol Cell. 2003; 14: 3470-81.Lefer DJ. Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection. Circ Res. 2006; 98: 10-1.Lefer DJ. Induction of HIF-1alpha and iNOS with siRNA: a novel mechanism for myocardial protection. Circ Res. 2006; 98: 10-1.Kasuno K, Takabuchi S, Fukuda K, et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem. 2004; 279: 2550-8.Kasuno K, Takabuchi S, Fukuda K, et al. Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling. J Biol Chem. 2004; 279: 2550-8.Sandau KB, Faus HG, Brune B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3 K pathway. Biochem Biophys Res Commun. 2000; 278: 263-7.Sandau KB, Faus HG, Brune B. Induction of hypoxia-inducible-factor 1 by nitric oxide is mediated via the PI 3 K pathway. Biochem Biophys Res Commun. 2000; 278: 263-7.Wang T, Leng YF, Zhang Y, et al. Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia. World J Gastroenterol. 2011; 17(14): 1915-22.Wang T, Leng YF, Zhang Y, et al. Oxidative stress and hypoxia-induced factor 1α expression in gastric ischemia. World J Gastroenterol. 2011; 17(14): 1915-22.Liang H, Yu F, Tong Z, et al. Effect of ischemia post-conditioning on skeletal muscle oxidative injury, mTOR, Bax, Bcl-2 proteins expression, and HIF-1α/β-actin mRNA, IL-6/ β-actin mRNA and caveolin-3/β-actin mRNA expression in ischemia-reperfusion rabbits. Mol Biol Rep. 2013; 40(1): 507-14. doi: 10.1007/s11033-012-2087-9.Liang H, Yu F, Tong Z, et al. Effect of ischemia post-conditioning on skeletal muscle oxidative injury, mTOR, Bax, Bcl-2 proteins expression, and HIF-1α/β-actin mRNA, IL-6/ β-actin mRNA and caveolin-3/β-actin mRNA expression in ischemia-reperfusion rabbits. Mol Biol Rep. 2013; 40(1): 507-14. doi: 10.1007/s11033-012-2087-9.

The authors declare that there are no conflicts of interest present.