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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1360</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>НАРУШЕНИЯ ФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ПРИ МЕТАБОЛИЧЕСКОМ СИНДРОМЕ В СОЧЕТАНИИ С АРТЕРИАЛЬНОЙ ГИПЕРТОНИЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>RENAL DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME AND ARTERIAL HYPERTENSION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарипова</surname><given-names>Г. Х.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharipova</surname><given-names>G. Kh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>докторант отдела системных гипертензий</p></bio><email xlink:type="simple">gulandom05@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чазова</surname><given-names>И. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Chazova</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>руководитель отдела системных гипертензий</p></bio><email xlink:type="simple">gulandom05@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Институт клинической кардиологии им. А.Л.Мясникова ФГУ РКНПК Росмедтехнологий, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2009</year></pub-date><pub-date pub-type="epub"><day>28</day><month>06</month><year>2009</year></pub-date><volume>0</volume><issue>3</issue><fpage>89</fpage><lpage>95</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шарипова Г.Х., Чазова И.Е., 2009</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="ru">Шарипова Г.Х., Чазова И.Е.</copyright-holder><copyright-holder xml:lang="en">Sharipova G.K., Chazova I.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1360">https://russjcardiol.elpub.ru/jour/article/view/1360</self-uri><abstract><p>.</p></abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мухин Н.А. Снижение скорости клубочковой фильтрации – общепопуляционный маркер неблагоприятного прогноза. Терапевтический архив, 2007 № 6, с. 5-10.</mixed-citation><mixed-citation xml:lang="en">Мухин Н.А. Снижение скорости клубочковой фильтрации – общепопуляционный маркер неблагоприятного прогноза. Терапевтический архив, 2007 № 6, с. 5-10.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Abuaisha B, Kumar S, Malik R, Boulton AJ. Relationship of elevated urinary albumin excretion to components of the metabolic syndrome in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1998 Feb;39(2):93-9.</mixed-citation><mixed-citation xml:lang="en">Abuaisha B, Kumar S, Malik R, Boulton AJ. Relationship of elevated urinary albumin excretion to components of the metabolic syndrome in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract. 1998 Feb;39(2):93-9.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Andronico G, Ferraro-Mortellaro R, Mangano MT, Rom M, Raspanti F, Pinto A, Licata G, Seddio G, Mul G, Cerasola G. Insulin resistance and glomerular hemodynamics in essential hypertension. Kidney Int. 2002 Sep;62(3):1005-9.</mixed-citation><mixed-citation xml:lang="en">Andronico G, Ferraro-Mortellaro R, Mangano MT, Rom M, Raspanti F, Pinto A, Licata G, Seddio G, Mul G, Cerasola G. Insulin resistance and glomerular hemodynamics in essential hypertension. Kidney Int. 2002 Sep;62(3):1005-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Barratt J, Topham P. Urine proteomics: the present and future of measuring urinary protein components in disease. CMAJ 2007; 177: 361-68.</mixed-citation><mixed-citation xml:lang="en">Barratt J, Topham P. Urine proteomics: the present and future of measuring urinary protein components in disease. CMAJ 2007; 177: 361-68.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Borch-Johnsen K, Feldt-Rasmussen B, Strandgaard S et al. Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study. Diabetologia 1998; 41: 694–700.</mixed-citation><mixed-citation xml:lang="en">Borch-Johnsen K, Feldt-Rasmussen B, Strandgaard S et al. Microalbuminuria is strongly associated with NIDDM and hypertension, but not with the insulin resistance syndrome: the Hoorn Study. Diabetologia 1998; 41: 694–700.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chagnac A, Weinstein T, Korzets A et al. Glomerular hemodynamics in severe obesity. Am J Physiol 2000; 278: F817–22.</mixed-citation><mixed-citation xml:lang="en">Chagnac A, Weinstein T, Korzets A et al. Glomerular hemodynamics in severe obesity. Am J Physiol 2000; 278: F817–22.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen J, Muntner P, Hamm LL et al. The metabolic syndrome and chronic kidney disease in US adults. Ann Intern Med 2004;140:167- 74.</mixed-citation><mixed-citation xml:lang="en">Chen J, Muntner P, Hamm LL et al. The metabolic syndrome and chronic kidney disease in US adults. Ann Intern Med 2004;140:167- 74.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ: National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report. JAMA 2003;289: 2560–2572.</mixed-citation><mixed-citation xml:lang="en">Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, Jones DW, Materson BJ, Oparil S, Wright JT Jr, Roccella EJ: National Heart, Lung, and Blood Institute Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure; National High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 report. JAMA 2003;289: 2560–2572.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">De La Sierra A, Bragulat E, Sierra C, Gomez-Angelats E, Antonio MT, Aguilera MT, Coca A.Microalbuminuria in essential hypertension: clinical and biochemical profile. Br J Biomed Sci. 2000;57(4):287-91.</mixed-citation><mixed-citation xml:lang="en">De La Sierra A, Bragulat E, Sierra C, Gomez-Angelats E, Antonio MT, Aguilera MT, Coca A.Microalbuminuria in essential hypertension: clinical and biochemical profile. Br J Biomed Sci. 2000;57(4):287-91.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Dengel DR, Goldberg AP, Mayuga RS, Kairis GM, Weir MR. Insulin resistance, elevated glomerular filtration fraction, and renal injury. Hypertension. 1996 Jul;28(1):127-32.</mixed-citation><mixed-citation xml:lang="en">Dengel DR, Goldberg AP, Mayuga RS, Kairis GM, Weir MR. Insulin resistance, elevated glomerular filtration fraction, and renal injury. Hypertension. 1996 Jul;28(1):127-32.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">ESH-ESC Guidelines Committee. European Society of Hypertension-European Society of Cardiology Guidelines Committee: 2007 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2007;25: 1105–1187.</mixed-citation><mixed-citation xml:lang="en">ESH-ESC Guidelines Committee. European Society of Hypertension-European Society of Cardiology Guidelines Committee: 2007 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2007;25: 1105–1187.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Fliser D, Pacini G, Engelleiter R, Kautzky-Willer A, Prager R, Franek E, Ritz E. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease. Kidney Int. 1998 May;53(5):1343-7.</mixed-citation><mixed-citation xml:lang="en">Fliser D, Pacini G, Engelleiter R, Kautzky-Willer A, Prager R, Franek E, Ritz E. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease. Kidney Int. 1998 May;53(5):1343-7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Grandi AM, Santillo R, Zanzi P, Broggi R, Imperiale D, Colombo S, Bertolini A, Jessula A, Selva E, Guasti L, Venco A. Microalbuminuria in never-treated hypertensives: lack of relationship to hyperinsulinemia and genetic predisposition to hypertension. Am J Hypertens. 2000 Apr;13(4 Pt 1):353-8.</mixed-citation><mixed-citation xml:lang="en">Grandi AM, Santillo R, Zanzi P, Broggi R, Imperiale D, Colombo S, Bertolini A, Jessula A, Selva E, Guasti L, Venco A. Microalbuminuria in never-treated hypertensives: lack of relationship to hyperinsulinemia and genetic predisposition to hypertension. Am J Hypertens. 2000 Apr;13(4 Pt 1):353-8.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Grundy SM, Brewer HB, Cleeman JI et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/ American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433–8.</mixed-citation><mixed-citation xml:lang="en">Grundy SM, Brewer HB, Cleeman JI et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/ American Heart Association conference on scientific issues related to definition. Circulation 2004; 109: 433–8.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Harrap SB, Cumming AD, Davies DL, Foy CJ, Fraser R, Kamitani A, Connor JM, Lever AF, Watt GC. Glomerular hyperfiltration, high renin, and low- extracellular volume in high blood pressure. Hypertension. 2000 Apr;35(4):952-7.</mixed-citation><mixed-citation xml:lang="en">Harrap SB, Cumming AD, Davies DL, Foy CJ, Fraser R, Kamitani A, Connor JM, Lever AF, Watt GC. Glomerular hyperfiltration, high renin, and low- extracellular volume in high blood pressure. Hypertension. 2000 Apr;35(4):952-7.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Hebert LA, Spetie DN, Keane WF. The urgent call of albuminuria/ proteinuria. Heeding its significance in early detection of kidney disease. Postgrad Med 2001; 110: 79-82, 87-8, 93-6.</mixed-citation><mixed-citation xml:lang="en">Hebert LA, Spetie DN, Keane WF. The urgent call of albuminuria/ proteinuria. Heeding its significance in early detection of kidney disease. Postgrad Med 2001; 110: 79-82, 87-8, 93-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann IS, Jimenez E, Cubeddu LX. Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure. J Hum Hypertens. 2001 Jun;15(6):407-12.</mixed-citation><mixed-citation xml:lang="en">Hoffmann IS, Jimenez E, Cubeddu LX. Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure. J Hum Hypertens. 2001 Jun;15(6):407-12.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kim YI, Kim CH, Choi CS, Chung YE, Lee MS, Lee SI, Park JY, Hong SK, Lee KU. Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population. Diabetes Res Clin Pract. 2001 May;52(2):145-52.</mixed-citation><mixed-citation xml:lang="en">Kim YI, Kim CH, Choi CS, Chung YE, Lee MS, Lee SI, Park JY, Hong SK, Lee KU. Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population. Diabetes Res Clin Pract. 2001 May;52(2):145-52.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kincaid-Smith P. Hypothesis: obesity and the insulin resistance syndrome play a major role in end stage renal failure attributed to hypertension and labeled „hypertensive nephrosclerosis“. J Hypertens 2004; 22: 1051-5.</mixed-citation><mixed-citation xml:lang="en">Kincaid-Smith P. Hypothesis: obesity and the insulin resistance syndrome play a major role in end stage renal failure attributed to hypertension and labeled „hypertensive nephrosclerosis“. J Hypertens 2004; 22: 1051-5.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Klausen K, Borch-Johnsen K, Feldt Rasmussen B, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004; 110: 32-5.</mixed-citation><mixed-citation xml:lang="en">Klausen K, Borch-Johnsen K, Feldt Rasmussen B, et al. Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function, hypertension, and diabetes. Circulation 2004; 110: 32-5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Hirakata H, Fujishima M. Effect of hyperinsulinemia on renal function in a general Japanese population: the Hisayama study. Kidney Int. 1999 Jun;55(6):2450-6.</mixed-citation><mixed-citation xml:lang="en">Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Hirakata H, Fujishima M. Effect of hyperinsulinemia on renal function in a general Japanese population: the Hisayama study. Kidney Int. 1999 Jun;55(6):2450-6.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenzo C, Nath SD, Hanley AJ, Abboud HE, Haffner SM.Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria. Clin J Am Soc Nephrol. 2008 May;3(3):783-9. Epub 2008 Mar 5.</mixed-citation><mixed-citation xml:lang="en">Lorenzo C, Nath SD, Hanley AJ, Abboud HE, Haffner SM.Relation of low glomerular filtration rate to metabolic disorders in individuals without diabetes and with normoalbuminuria. Clin J Am Soc Nephrol. 2008 May;3(3):783-9. Epub 2008 Mar 5.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Mul G, Nardi E, Cottone S, Cusimano P, Volpe V, Piazza G, Mongiov R, Mezzatesta G, Andronico G, Cerasola G. Influence of metabolic syndrome on hypertension-related target organ damage. J Intern Med. 2005 Jun;257(6):503-13.</mixed-citation><mixed-citation xml:lang="en">Mul G, Nardi E, Cottone S, Cusimano P, Volpe V, Piazza G, Mongiov R, Mezzatesta G, Andronico G, Cerasola G. Influence of metabolic syndrome on hypertension-related target organ damage. J Intern Med. 2005 Jun;257(6):503-13.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mykkanen L, Zaccaro DJ, Wagenknecht LE et al. Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the Insulin Resistance Atherosclerosis Study. Diabetes 1998; 47: 793– 800.</mixed-citation><mixed-citation xml:lang="en">Mykkanen L, Zaccaro DJ, Wagenknecht LE et al. Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the Insulin Resistance Atherosclerosis Study. Diabetes 1998; 47: 793– 800.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamura K., Okamura T., Hayakawa T., et al. Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan: NIPPON DATA 90. Circ. J. 2006:70(8):954-959.</mixed-citation><mixed-citation xml:lang="en">Nakamura K., Okamura T., Hayakawa T., et al. Chronic kidney disease is a risk factor for cardiovascular death in a community-based population in Japan: NIPPON DATA 90. Circ. J. 2006:70(8):954-959.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Okpechi IG, Pascoe MD, Swanepoel CR, Rayner BL. Microalbuminuria and the metabolic syndrome in non-diabetic black Africans. Diab Vasc Dis Res. 2007 Dec;4(4):365-7.</mixed-citation><mixed-citation xml:lang="en">Okpechi IG, Pascoe MD, Swanepoel CR, Rayner BL. Microalbuminuria and the metabolic syndrome in non-diabetic black Africans. Diab Vasc Dis Res. 2007 Dec;4(4):365-7.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Palaniappan L, Carnethon M, Fortmann SP. Association between microalbuminuria and the metabolic syndrome: NHANES III. Am J Hypertens 2003; 16: 952–8.</mixed-citation><mixed-citation xml:lang="en">Palaniappan L, Carnethon M, Fortmann SP. Association between microalbuminuria and the metabolic syndrome: NHANES III. Am J Hypertens 2003; 16: 952–8.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Pedrinelli R, Dell’Omo G, Penno G, Di Bello V, Giorgi D, Pellegrini G, Del Prato S, Mariani M.Microalbuminuria, a parameter independent of metabolic influences in hypertensive men. J Hypertens 2003 Jun;21(6):1163-9.</mixed-citation><mixed-citation xml:lang="en">Pedrinelli R, Dell’Omo G, Penno G, Di Bello V, Giorgi D, Pellegrini G, Del Prato S, Mariani M.Microalbuminuria, a parameter independent of metabolic influences in hypertensive men. J Hypertens 2003 Jun;21(6):1163-9.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pontremoli R, Leoncini G, Viazzi F, Ratto E, Vaccaro V, Falqui V, Parodi A, Conti N, Tomolillo C, Deferrari G. Evaluation of Subclinical Organ Damage for Risk Assessment and Treatment in the Hypertensive Patient: Role of Microalbuminuria. J Am Soc Nephrol 2006;17: S112–S114.</mixed-citation><mixed-citation xml:lang="en">Pontremoli R, Leoncini G, Viazzi F, Ratto E, Vaccaro V, Falqui V, Parodi A, Conti N, Tomolillo C, Deferrari G. Evaluation of Subclinical Organ Damage for Risk Assessment and Treatment in the Hypertensive Patient: Role of Microalbuminuria. J Am Soc Nephrol 2006;17: S112–S114.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rayner B. Importance of modulating the renin-angiotensin system in preventing renal complications of hypertension. Saudi J Kidney Dis Transpl 2006; 17: 469-80.</mixed-citation><mixed-citation xml:lang="en">Rayner B. Importance of modulating the renin-angiotensin system in preventing renal complications of hypertension. Saudi J Kidney Dis Transpl 2006; 17: 469-80.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Redon J, Miralles A, Pascual JM, Bald E, Robles RG, Carmena R. Hyperinsulinemia as a determinant of microalbuminuria in essential hypertension. J Hypertens. 1997 Jan;15(1):79-86.</mixed-citation><mixed-citation xml:lang="en">Redon J, Miralles A, Pascual JM, Bald E, Robles RG, Carmena R. Hyperinsulinemia as a determinant of microalbuminuria in essential hypertension. J Hypertens. 1997 Jan;15(1):79-86.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Rossing P, Hougaard P, Borch-Johnsen K, Parving HH. Predictors of mortality in insulin dependent diabetes: 10 year obser vational follow up study. BMJ 1996; 313: 779-84.</mixed-citation><mixed-citation xml:lang="en">Rossing P, Hougaard P, Borch-Johnsen K, Parving HH. Predictors of mortality in insulin dependent diabetes: 10 year obser vational follow up study. BMJ 1996; 313: 779-84.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ruilope LM, van Veldhuisen DJ, Ritz E, Luscher TF. Renal function: the Cinderella of cardiovascular risk profile. J Am Coll Cardiol 2001; 38: 1782-87.</mixed-citation><mixed-citation xml:lang="en">Ruilope LM, van Veldhuisen DJ, Ritz E, Luscher TF. Renal function: the Cinderella of cardiovascular risk profile. J Am Coll Cardiol 2001; 38: 1782-87.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Scaglione R, Argano C, di Chiara T, Colomba D, Parrinello G, Corrao S, Avellone G, Licata G.Central obesity and hypertensive renal disease: association between higher levels of BMI, circulating transforming growth factor beta1 and urinary albumin excretion. Blood Press. 2003;12(5-6):269-76.</mixed-citation><mixed-citation xml:lang="en">Scaglione R, Argano C, di Chiara T, Colomba D, Parrinello G, Corrao S, Avellone G, Licata G.Central obesity and hypertensive renal disease: association between higher levels of BMI, circulating transforming growth factor beta1 and urinary albumin excretion. Blood Press. 2003;12(5-6):269-76.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Schmieder RE, Veelken R, Schobel H, Dominiak P, Mann JF, Luft FC. Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension. J Am Soc Nephrol. 1997 Jun;8(6):893-900.</mixed-citation><mixed-citation xml:lang="en">Schmieder RE, Veelken R, Schobel H, Dominiak P, Mann JF, Luft FC. Glomerular hyperfiltration during sympathetic nervous system activation in early essential hypertension. J Am Soc Nephrol. 1997 Jun;8(6):893-900.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Schrader J, Luders S, Kulschewski A, et al. Microalbuminuria and tubular proteinuria as risk predictors of cardiovascular morbidity and mortality in essential hypertension: final results of a prospective long-term study (MARPLE Study)*. J Hypertens 2006; 24: 541-8.</mixed-citation><mixed-citation xml:lang="en">Schrader J, Luders S, Kulschewski A, et al. Microalbuminuria and tubular proteinuria as risk predictors of cardiovascular morbidity and mortality in essential hypertension: final results of a prospective long-term study (MARPLE Study)*. J Hypertens 2006; 24: 541-8.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Srinivasan SR, Myers L, Berenson GS. Risk variables of insulin resistance syndrome in African American and Caucasian young adults with microalbuminuria: the Bogalusa Heart Study. Am J Hypertens 2000; 13: 1274–9.</mixed-citation><mixed-citation xml:lang="en">Srinivasan SR, Myers L, Berenson GS. Risk variables of insulin resistance syndrome in African American and Caucasian young adults with microalbuminuria: the Bogalusa Heart Study. Am J Hypertens 2000; 13: 1274–9.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Sukhija R, Aronow WS, Kakar P, et al. Relation of microalbuminuria and coro nary artery disease in patients with and without diabetes mellitus. Am J Cardiol 2006; 98: 279-81.</mixed-citation><mixed-citation xml:lang="en">Sukhija R, Aronow WS, Kakar P, et al. Relation of microalbuminuria and coro nary artery disease in patients with and without diabetes mellitus. Am J Cardiol 2006; 98: 279-81.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">ter Maaten JC, Bakker SJ, Sern EH, ter Wee PM, Donker AJ, Gans RO. Insulin’s acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin’s acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects. Nephrol Dial Transplant. 1999 Oct;14(10):2357-63.</mixed-citation><mixed-citation xml:lang="en">ter Maaten JC, Bakker SJ, Sern EH, ter Wee PM, Donker AJ, Gans RO. Insulin’s acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin’s acute effects on proximal tubular sodium reabsorption correlation with salt sensitivity in normal subjects. Nephrol Dial Transplant. 1999 Oct;14(10):2357-63.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Valensi P, Assayag M, Busby M, Pari s J, Lormeau B, Attali JR. Microalbuminuria in obese patients with or without hypertension. Int J Obes Relat Metab Disord. 1996 Jun;20(6):574-9.</mixed-citation><mixed-citation xml:lang="en">Valensi P, Assayag M, Busby M, Pari s J, Lormeau B, Attali JR. Microalbuminuria in obese patients with or without hypertension. Int J Obes Relat Metab Disord. 1996 Jun;20(6):574-9.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton PK, He J, Perneger TV, Klag MJ. Kidney damage in ‘benign’ essential hypertension. Curr Opin Nephrol Hypertens. 1997 Mar;6(2):177-83.</mixed-citation><mixed-citation xml:lang="en">Whelton PK, He J, Perneger TV, Klag MJ. Kidney damage in ‘benign’ essential hypertension. Curr Opin Nephrol Hypertens. 1997 Mar;6(2):177-83.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
