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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1560-4071-2017-8-24-30</article-id><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1268</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>СРАВНИТЕЛЬНЫЙ АНАЛИЗ НАРУШЕНИЯ МЕХАНИЧЕСКОЙ ФУНКЦИИ ЛЕВОГО ПРЕДСЕРДИЯ ПОСЛЕ ПРОЦЕДУРЫ АНТРАЛЬНОЙ ИЗОЛЯЦИИ ЛЕГОЧНЫХ ВЕН МЕТОДОМ РАДИОЧАСТОТНОЙ И КРИОБАЛОННОЙ АБЛАЦИИ</article-title><trans-title-group xml:lang="en"><trans-title>COMPARISON OF THE DISORDERED MECHANICAL FUNCTION OF THE LEFT ATRIUM AFTER ANTRAL ISOLATION OF PULMONARY VEINS BY RADIOFREQUENCY OR CRYOBALLOON ABLATION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамчур</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamchur</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник лаборатории ультразвуковых и электрофизиологических методов диагностики НИИ КПССЗ</p></bio><email xlink:type="simple">mamchuririna77@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чичкова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Chichkova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник лаборатории нарушения ритма сердца и электрокардиостимуляции НИИ КПССЗ</p></bio><email xlink:type="simple">chi4cova@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мамчур</surname><given-names>С. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mamchur</surname><given-names>S. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий лабораторией нарушения ритма сердца и электрокардиостимуляции НИИ КПССЗ</p></bio><email xlink:type="simple">sergei_mamchur@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бохан</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Bokhan</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач отделения рентгенхирургических методов диагностики и лечения</p></bio><email xlink:type="simple">nikitabokhan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>М. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>M. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>младший научный сотрудник лаборатории нарушения ритма сердца и электрокардиостимуляции НИИ КПССЗ</p></bio><email xlink:type="simple">mariya.romanova.80@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хоменко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khomenko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>старший научный сотрудник лаборатории нарушения ритма сердца и электрокардиостимуляции НИИ КПССЗ</p></bio><email xlink:type="simple">homea@kemcardio.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний"</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2017</year></pub-date><volume>0</volume><issue>8</issue><fpage>24</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мамчур И.Н., Чичкова Т.Ю., Мамчур С.Е., Бохан Н.С., Романова М.П., Хоменко Е.А., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Мамчур И.Н., Чичкова Т.Ю., Мамчур С.Е., Бохан Н.С., Романова М.П., Хоменко Е.А.</copyright-holder><copyright-holder xml:lang="en">Mamchur I.N., Chichkova T.Y., Mamchur S.E., Bokhan N.S., Romanova M.P., Khomenko E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1268">https://russjcardiol.elpub.ru/jour/article/view/1268</self-uri><abstract><p>Цель исследования – изучить и сравнить механическую функцию левого предсердия до и непосредственно после выполнения криобаллонной и радиочастотной изоляции легочных вен.</p><sec><title>Материал и методы</title><p>Материал и методы. В исследование включено 43 пациента с симптомной фибрилляцией предсердий, устойчивой к антиаритмической терапии. Из них 21 кандидат на криобаллонную изоляцию легочных вен, в возрасте 57,8±8,7 лет (из них 11 мужчин и 10 женщин) и 22 кандидата на радиочастотную аблацию в возрасте 54,4±11 лет, из которых было 6 женщин и 16 мужчин. До процедуры, тотчас после нее и на пятые сутки выполнялась трансторакальная эхокардиография с определением допплерографических характеристик внутрисердечной гемодинамики, а также оценку механической функции левого предсердия, в том числе с использованием его 3D-реконструкции.</p></sec><sec><title>Результаты</title><p>Результаты. По данным трансторакальной эхокардиографии и прямой интраоперационной манометрии выявлены значимые нарушения механической функции ЛП и в группе РЧА и в группе криоаблации с некоторыми межгрупповыми различиями. Изоляция легочных вен любым из методов не влияет на диастолическую и систолическую функцию ЛЖ, что подтверждается отсутствием динамики инвазивно измеренного КДД ЛЖ, а также изменения объемов и ФВ ЛЖ по данным эхокардиографии. Поэтому динамика трансмитрального кровотока, кровотока в легочных венах и легочной артерии, сопутствующая процедуре изоляции легочных вен, является следствием нарушения механической функции ЛП, связанного с ухудшением его пассивной растяжимости и активной сократимости, нарушением функции муфт ЛВ, увеличением легочного сосудистого сопротивления. Выявлено значимое снижение насосной функции ЛП, более выраженное в группе РЧА непосредственно сразу после процедуры, с последующим выравниванием значений на 5-е сутки после вмешательства. Также повысилось среднее давление в легочной артерии, причем к 5 суткам в группе РЧА оно было значимо выше, чем в группе криоаблации.</p></sec><sec><title>Заключение</title><p>Заключение. И криобаллонная и радиочастотная изоляция легочных вен в значительной степени нарушает механическую функцию левого предсердия, однако криобалонная аблация вызывает менее выраженные ее изменения в ближайшем послеоперационном периоде, чем радиочастотная.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess and compare mechanical functioning of the left atrium before and just after cryoballoon or radiofrequency ablation.</p></sec><sec><title>Material and methods</title><p>Material and methods. Totally, 43 patients included, with sympthomatic atrial fibrillation resistant to drug treatment. Of those 21 — for cryoballoon ablation (mean age 57,8±8,7 y. o., 11 males and 10 females) and 22 candidates for radiofrequency ablation, at the age 54,4±11 y. o., 16 males and 6 females. Before procedure, just after and on the 5th day, transthoracal echocardiography was performed, with measurement of Doppler parameters of intracardiac hemodynamics, as mechanical function of the left atrium assessment, including 3D imaging.</p></sec><sec><title>Results</title><p>Results. By the data from transthoracal echocardiography and direct intraoperation manometry, the significant disorders of the left atrium (LA) mechanical function were found in both treatment groups, with some differences. Pulmonary veins (PV) isolation by any method does not influence diastolic and systolic function of the left ventricle, that confirmed by invasive measurements of the end-diastolic pressure in LV, as the changes of volumes and ejection fraction by echocardiography. Therefore transmitral blood flow dynamics, as PV and pulmonary artery flow, related to PV isolation procedure, is a result of the LA functioning disorder due to its passive dilatability and active contractility decrease, dysfunction of the PV sleeves, increase of pulmonary vascular resistance. The significant decrease found in LA pumping function, more prominent in radiofrequency group just after the procedure, with further improvement to the 5th day after procedure. Also, mean pulmonary artery pressure increase, and till the 5th day in radiofrequency group it was significantly higher than in cryoablation group.</p></sec><sec><title>Conclusion</title><p>Conclusion. Both cryo and radio ablation procedures of PV isolation significantly impact on the mechanical functioning of the LA, however cryo ablation leads to less severe disorder at short follow-up.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>криоаблация</kwd><kwd>радиочастотная аблация</kwd><kwd>изоляция легочных вен</kwd><kwd>левое предсердие</kwd><kwd>механическая функция</kwd><kwd>сократимость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>cryoablation</kwd><kwd>radiofrequency ablation</kwd><kwd>pulmonary veins isolation</kwd><kwd>left atrium</kwd><kwd>mechanical function</kwd><kwd>contractility</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bockeria LA, Shengelia LD. Treatment of atrial fibrillation. Part I. Long way to the “Gold standard”. Annals of Arrhythmology. 2014; 11(2): 64-76. 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