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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">russjcardiol</journal-id><journal-title-group><journal-title xml:lang="ru">Российский кардиологический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian Journal of Cardiology</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1560-4071</issn><issn pub-type="epub">2618-7620</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">russjcardiol-1238</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group></article-categories><title-group><article-title>ИНГИБИТОР If-КАНАЛОВ ИВАБРАДИН В ЛЕЧЕНИИ БОЛЬНЫХ ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ: ВРЕМЯ ДЕБАТОВ ПРОШЛО, ПОРА ДЕЙСТВОВАТЬ</article-title><trans-title-group xml:lang="en"><trans-title>IF CHANNEL INHIBITOR IVABRADINE AND CHRONIC HEART FAILURE MANAGEMENT: FROM DISCUSSION TO ACTION</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лопатин</surname><given-names>Ю. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lopatin</surname><given-names>Yu. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий кафедрой кардиологии ФУВ ВГМУ, заведующий отделом ВОКЦ</p></bio><email xlink:type="simple">prof_lopatin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФУВ Волгоградский государственный медицинский университет, Волгоградский областной кардиологический центр, Волгоград</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd State Medical University, Volgograd Region Cardiology Centre, Volgograd</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>08</month><year>2012</year></pub-date><volume>0</volume><issue>4</issue><fpage>6</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лопатин Ю.М., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Лопатин Ю.М.</copyright-holder><copyright-holder xml:lang="en">Lopatin Y.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://russjcardiol.elpub.ru/jour/article/view/1238">https://russjcardiol.elpub.ru/jour/article/view/1238</self-uri><abstract><p>Статья посвящена результатам рандомизированного клинического испытания SHIFT, которое определило начало дискуссии о выборе оптимальной тактики пульс-урежающей терапии у больных с хронической сердечной недостаточностью. Обсуждаются преимущества включения в схему лечения больных с хронической сердечной недостаточностью ингибитора If-каналов ивабрадина, а также позиция препарата в современных рекомендациях по ведению данной категории пациентов.</p><sec><title> </title><p> </p></sec><sec><title> </title><p> </p></sec></abstract><trans-abstract xml:lang="en"><p>The paper is focused on the results of a randomised clinical trial SHIFT, which started the discussion about the choice of optimal heart rate-lowering therapy in patients with chronic heart failure (CHF). The author summarizes the benefits of adding an If channel inhibitor ivabradine to the standard CHF therapy and presents the place of this medication in the modern clinical guidelines on CHF management.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>бета-блокаторы</kwd><kwd>ингибитор If-каналов ивабрадин</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>beta-blockers</kwd><kwd>If channel inhibitor ivabradine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Swedberg K., Komajda M., Bohm M. et al. on behalf of the SHIFT investigators. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomized placebo-controlled study. Lancet. 2010; 376: 875–85.</mixed-citation><mixed-citation xml:lang="en">Swedberg K., Komajda M., Bohm M. et al. on behalf of the SHIFT investigators. 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