russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLCrussjcardiol-1235Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWHELICOBACTER PYLORI И ПАТОЛОГИЯ СЕРДЕЧНО-СОСУДИСТОЙ СИСТЕМЫ: ДЕЙСТВИТЕЛЬНО ЛИ ПУТЬ К СЕРДЦУ ЛЕЖИТ ЧЕРЕЗ ЖЕЛУДОК?HELICOBACTER PYLORI AND CARDIOVASCULAR DISEASE: THE ROAD TO THE HEART IS THROUGH THE STOMACH?МартусевичА. К.MartusevichA. K.

к.м.н., проф. РАЕН, с.н.с. отделения экспериментальной медицины ФГУ «ННИИТО»

cryst-mart@yandex.ruСимоноваЖ. Г.SimonovaZh. G.

к.м.н., асс. каф. госпитальной терапии

cryst-mart@yandex.ruТарловскаяЕ. И.TarlovskayaE. I.

д.м.н., проф. кафедры госпитальной терапии, член правления Всероссийского научного общества кардиологов

cryst-mart@yandex.ruФГБУ «Нижегородский научно-исследовательский институт травматологии и ортопедии», Нижний НовгородРоссияNizhny Novgorod Research Institute of Traumatology and Orthopedics, Nizhny NovgorodRussian FederationГОУ ВПО «Кировская государственная медицинская академия», КировРоссияKirov State Medical Academy, KirovRussian Federation2012280620120391101Copyright © Мартусевич А.К., Симонова Ж.Г., Тарловская Е.И., 20122012Мартусевич А.К., Симонова Ж.Г., Тарловская Е.И.Martusevich A.K., Simonova Z.G., Tarlovskaya E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/1235

В статье приводятся и анализируются данные отечественной и зарубежной литературы о потенциальной связи хеликобактерной инфекции и риска развития и прогрессирования кардиоваскулярной патологии. Рассматриваются имеющиеся статистические доказательства ее существования, эффективность превентивной эрадикационной терапии, а также сведения о вариантах патогенетических механизмов формирования указанной связи. На основании критического анализа данных литературы и некоторых собственных исследований предлагается новая интегральная концепция патогенеза Helicobacter Pylori-ассоциированных заболеваний сердечно-сосудистой системы.

 

The paper analyses the Russian and international evidence on the potential role of Helicobacter pylori infection in the development and progression of cardiovascular disease. The authors discuss the existing statistical evidence of this association, its pathogenetic mechanisms, and the effectiveness of preventive eradication treatment. Based on the literature data and the original research findings, the authors propose a new complex concept of the pathogenesis of Helicobacter pyloriassociated cardiovascular disease.

Helicobacter Pyloriишемическая болезнь сердцаинфаркт миокардаатеросклерозпатогенезHelicobacter pyloricoronary heart diseasemyocardial infarctionatherosclerosispathogenesisReferencesVasil’ev Ju. V. Acid-associated diseases of gastrointestinal tract and coronary artery disease. Lechawij vrach 2006; 1: 50–55. Russian (Васильев Ю. В. Кислотозависимые заболевания ЖКТ и ишемическая болезнь сердца. Лечащий врач 2006; 1: 50–55).Vasil’ev Ju. V. Acid-associated diseases of gastrointestinal tract and coronary artery disease. Lechawij vrach 2006; 1: 50–55. Russian (Васильев Ю. В. Кислотозависимые заболевания ЖКТ и ишемическая болезнь сердца. Лечащий врач 2006; 1: 50–55).Isakov V.A., Domaradskij I.V. Helicobacteriosis. Moscow: Medpraktika; 2003. Russian (Исаков В.А., Домарадский И.В. Хеликобактериоз.М.: Медпрактика; 2003).Isakov V.A., Domaradskij I.V. Helicobacteriosis. Moscow: Medpraktika; 2003. Russian (Исаков В.А., Домарадский И.В. Хеликобактериоз.М.: Медпрактика; 2003).Cammarota G. et al. Helicobacter Pylori is an aetiological factor for ischaemic heart disease: the case against. Dig. Liver Dis. 2000; 32 (1): 65–68.Cammarota G. et al. Helicobacter Pylori is an aetiological factor for ischaemic heart disease: the case against. Dig. Liver Dis. 2000; 32 (1): 65–68.Mayr M. et al. Increased risk of atherosclerosis is confined to CagA-positive Helicobacter Pylori strains: prospective results from the Bruneck study. Stroke 2003: 34 (3): 610–615.Mayr M. et al. Increased risk of atherosclerosis is confined to CagA-positive Helicobacter Pylori strains: prospective results from the Bruneck study. Stroke 2003: 34 (3): 610–615.Zhang S.et al. Cytotoxin-associated gene-A seropositive virulent strains of Helicobacter Pylori and atherosclerotic diseases: a systematic review. Chin. Med.J. 2008; 121 (10): 946–951.Zhang S.et al. Cytotoxin-associated gene-A seropositive virulent strains of Helicobacter Pylori and atherosclerotic diseases: a systematic review. Chin. Med.J. 2008; 121 (10): 946–951.Delaney B.C., Hobbs F.D., Holder R. Association of Helicobacter Pylori infection with coronary heart disease. Eradication of the infection on grounds of cardiovascular risk is not supported by current evidence. Br. Med.J. 1996; 312: 251–252.Delaney B.C., Hobbs F.D., Holder R. Association of Helicobacter Pylori infection with coronary heart disease. Eradication of the infection on grounds of cardiovascular risk is not supported by current evidence. Br. Med.J. 1996; 312: 251–252.Pasceri V. et al. Association of virulent Helicobacter Pylori strains with ischemic heart disease. Circulation 1998; 97: 1675–1679.Pasceri V. et al. Association of virulent Helicobacter Pylori strains with ischemic heart disease. Circulation 1998; 97: 1675–1679.Patel P. et al. Association of Helicobacter Pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. Br. Med.J. 1995; 311: 711–714.Patel P. et al. Association of Helicobacter Pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors. Br. Med.J. 1995; 311: 711–714.Wald N.J. et al. Helicobacter Pylori infection and mortality from ischaemic heart disease: negative result from a large, prospective study//Br. Med. J.– 1997.– Vol. 315.– P. 1199– 1201.Wald N.J. et al. Helicobacter Pylori infection and mortality from ischaemic heart disease: negative result from a large, prospective study//Br. Med. J.– 1997.– Vol. 315.– P. 1199– 1201.Monaco C. et al. Persistent systemic inflammation in unstable angina is largely unrelated to the atherothrombotic burden.J. Am. Coll. Cardiol. 2005; 45 (2): 238–243.Monaco C. et al. Persistent systemic inflammation in unstable angina is largely unrelated to the atherothrombotic burden.J. Am. Coll. Cardiol. 2005; 45 (2): 238–243.Pietroiusti A. et al. Cytotoxin-associated Gene A positive Helicobacter Pylori strains are associated with atherosclerotic stroke. Circulation 2002; 106: 580–584.Pietroiusti A. et al. Cytotoxin-associated Gene A positive Helicobacter Pylori strains are associated with atherosclerotic stroke. Circulation 2002; 106: 580–584.Aceti А., Are R., Sabino G. et al. Helicobacter Pylori-active infection in patients with acute coronary heart disease.J. Infect. 2004; 49: 8–12.Aceti А., Are R., Sabino G. et al. Helicobacter Pylori-active infection in patients with acute coronary heart disease.J. Infect. 2004; 49: 8–12.Franceschi F. et al. CagA antigen of Helicobacter Pylori and coronary instability: insight from a clinico-pathological study and a meta-analysis of 4241 cases. Atherosclerosis 2009; 202 (2): 535–542.Franceschi F. et al. CagA antigen of Helicobacter Pylori and coronary instability: insight from a clinico-pathological study and a meta-analysis of 4241 cases. Atherosclerosis 2009; 202 (2): 535–542.Pellicano R. et al. Helicobacter Pylori and coronary heart disease: which directions for future studies? Crit. Rev. Microbiol. 2003; 29 (4): 351–359.Pellicano R. et al. Helicobacter Pylori and coronary heart disease: which directions for future studies? Crit. Rev. Microbiol. 2003; 29 (4): 351–359.Andri R. et al. Prevalence of intimal pathogen burden in acute coronary syndromes.Z. Kardiol. 2003; 92 (8): 641–649.Andri R. et al. Prevalence of intimal pathogen burden in acute coronary syndromes.Z. Kardiol. 2003; 92 (8): 641–649.Conway D.S., Lip G. Y. Helicobacter Pylori as the cause of coronary artery restenosis following angioplasty – is the way to a man’s heart disease through his stomach? Dig. Liver Dis. 2001; 33 (3): 214–216.Conway D.S., Lip G. Y. Helicobacter Pylori as the cause of coronary artery restenosis following angioplasty – is the way to a man’s heart disease through his stomach? Dig. Liver Dis. 2001; 33 (3): 214–216.Birnie D. et al. Association between antibodies to mycobacterial heat shock protein 65 and coronary atherosclerosis: possible mechanism of action of Helicobacter Pylori in increasing cardiovascular risk. Heart 1996; 75 (Suppl. 1): 49.Birnie D. et al. Association between antibodies to mycobacterial heat shock protein 65 and coronary atherosclerosis: possible mechanism of action of Helicobacter Pylori in increasing cardiovascular risk. Heart 1996; 75 (Suppl. 1): 49.Rasmi Y., Raeisi S. Possible role of Helicobacter Pylori infection via microvascular dysfunction in cardiac syndrome X. Cardiol.J. 2009; 16 (6): 585–587.Rasmi Y., Raeisi S. Possible role of Helicobacter Pylori infection via microvascular dysfunction in cardiac syndrome X. Cardiol.J. 2009; 16 (6): 585–587.Lanza G.A. et al. Assessment of systemic inflammation and infective pathogen burden in patients with cardiac syndrome X. Am.J. Cardiol. 2004; 94 (1): 40–44.Lanza G.A. et al. Assessment of systemic inflammation and infective pathogen burden in patients with cardiac syndrome X. Am.J. Cardiol. 2004; 94 (1): 40–44.Nocente R. et al. Resolution of syndrome X after eradication of virulent CagA-positive Helicobacter Pylori. South Med. J. 2000; 93 (10): 1022–1023.Nocente R. et al. Resolution of syndrome X after eradication of virulent CagA-positive Helicobacter Pylori. South Med. J. 2000; 93 (10): 1022–1023.Kratnov A. E., Pavlov O. N. Helicobacter Pylori infection and antioxidant protection state at patients with unstable coronary disease. Jeksperimental’naja i klinicheskaja gastrojenterologija 2004; 5: 4–9. Russain (Кратнов А. Е., Павлов О. Н. Инфекция Helicobacter Pylori и состояние антиоксидантной защиты у пациентов с нестабильным течением ишемической болезни сердца. Экспериментальная и клиническая гастроэнтерология 2004; 5: 4–9.Kratnov A. E., Pavlov O. N. Helicobacter Pylori infection and antioxidant protection state at patients with unstable coronary disease. Jeksperimental’naja i klinicheskaja gastrojenterologija 2004; 5: 4–9. Russain (Кратнов А. Е., Павлов О. Н. Инфекция Helicobacter Pylori и состояние антиоксидантной защиты у пациентов с нестабильным течением ишемической болезни сердца. Экспериментальная и клиническая гастроэнтерология 2004; 5: 4–9.Biasucci L.M. et al. Elevated levels of C reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999; 99 (7): 855–860.Biasucci L.M. et al. Elevated levels of C reactive protein at discharge in patients with unstable angina predict recurrent instability. Circulation 1999; 99 (7): 855–860.Altannavch Ts. et al. Serological markers of Chl. pneumoniae, cytomegalovirus and H. pylori infection in diabetic and non-diabetic patients with unstable angina pectoris. Cent. Eur. J. Public Health 2003; 11 (2): 102–106.Altannavch Ts. et al. Serological markers of Chl. pneumoniae, cytomegalovirus and H. pylori infection in diabetic and non-diabetic patients with unstable angina pectoris. Cent. Eur. J. Public Health 2003; 11 (2): 102–106.Choussat R. et al. Effect of prior exposure to Chlamydia pneumoniae, Helicobacter Pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q wave acute myocardial infarction. Am. J. Cardiol. 2000; 86 (4): 379–384.Choussat R. et al. Effect of prior exposure to Chlamydia pneumoniae, Helicobacter Pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q wave acute myocardial infarction. Am. J. Cardiol. 2000; 86 (4): 379–384.Rechciński T. et al. A comparison of titers of immunoglobulins A and G reacting with Helicobacter Pylori antigens in patients with unstable angina and symptomless blood donors. Pol. Arch. Med. Wewn. 1999; 102 (5): 973–978.Rechciński T. et al. A comparison of titers of immunoglobulins A and G reacting with Helicobacter Pylori antigens in patients with unstable angina and symptomless blood donors. Pol. Arch. Med. Wewn. 1999; 102 (5): 973–978.Wierzbicki W.B., Hagmeyer K. O. Helicobacter Pylori, Chlamydia pneumoniae, and cytomegalovirus: chronic infections and coronary heart disease. Pharmacotherapy 2000; 20 (1): 52–63.Wierzbicki W.B., Hagmeyer K. O. Helicobacter Pylori, Chlamydia pneumoniae, and cytomegalovirus: chronic infections and coronary heart disease. Pharmacotherapy 2000; 20 (1): 52–63.Oshima T. et al. Association of Helicobacter Pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J. Am. Coll. Card. 2005; 45: 1219–1222.Oshima T. et al. Association of Helicobacter Pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J. Am. Coll. Card. 2005; 45: 1219–1222.Colizzi C. et al. In vitro hyperreactivity to lipopolysaccharide in patients with history of unstable angina is not associated with seropositivity for Cytomegalovirus, Helicobacter Pylori and Chlamydia pneumonia. Cardiologia 1999; 44 (4): 377–380.Colizzi C. et al. In vitro hyperreactivity to lipopolysaccharide in patients with history of unstable angina is not associated with seropositivity for Cytomegalovirus, Helicobacter Pylori and Chlamydia pneumonia. Cardiologia 1999; 44 (4): 377–380.Grabczewska Z., Nartowicz E. Infections with Chlamydia pneumoniae, Helicobacter Pylori or cytomegalovirus and atherosclerosis. Przegl. Lek. 1999; 56 (9): 584–587.Grabczewska Z., Nartowicz E. Infections with Chlamydia pneumoniae, Helicobacter Pylori or cytomegalovirus and atherosclerosis. Przegl. Lek. 1999; 56 (9): 584–587.Mayr M. et al. Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter Pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis. Circulation 2000; 102 (8): 833–839.Mayr M. et al. Infections, immunity, and atherosclerosis: associations of antibodies to Chlamydia pneumoniae, Helicobacter Pylori, and cytomegalovirus with immune reactions to heat-shock protein 60 and carotid or femoral atherosclerosis. Circulation 2000; 102 (8): 833–839.Koenig W. et al. Infection with Helicobacter Pylori is not a major independent risk factor for stable coronary heart disease: lack of a role of cytotoxin-associated protein A positive strains and absence of a systemic inflammatory response. Circulation 1999; 100 (23): 2326–2331.Koenig W. et al. Infection with Helicobacter Pylori is not a major independent risk factor for stable coronary heart disease: lack of a role of cytotoxin-associated protein A positive strains and absence of a systemic inflammatory response. Circulation 1999; 100 (23): 2326–2331.Andraws R., Berger J.S., Brown D. L. Effects of antibiotic therapy on outcomes of patients with coronary artery disease. A meta-analysis of randomized controlled trials. JAMA 2005; 293 (21): 2641–2647.Andraws R., Berger J.S., Brown D. L. Effects of antibiotic therapy on outcomes of patients with coronary artery disease. A meta-analysis of randomized controlled trials. JAMA 2005; 293 (21): 2641–2647.Stone A. F.M. et al. Effect of treatment for Chlamydia pneumoniae and Helicobacter Pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation 2002; 106: 1219–1223.Stone A. F.M. et al. Effect of treatment for Chlamydia pneumoniae and Helicobacter Pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes: South Thames Trial of Antibiotics in Myocardial Infarction and Unstable Angina (STAMINA). Circulation 2002; 106: 1219–1223.Umreda M. et al. Helicobacter Pylori CagA causes mitotic impairment and induces chrom osomal instability.J. Biol. Chem. 2009; 284 (33): 22166–22172.Umreda M. et al. Helicobacter Pylori CagA causes mitotic impairment and induces chrom osomal instability.J. Biol. Chem. 2009; 284 (33): 22166–22172.Waidner B. et al. A novel system of cytoskeletal elements in the human pathogen Helicobacter Pylori. PLoS Pathog. 2007; 5 (11): e1000669.Waidner B. et al. A novel system of cytoskeletal elements in the human pathogen Helicobacter Pylori. PLoS Pathog. 2007; 5 (11): e1000669.Zealter Z. et al. Analysis of detergent-resistant membranes of Helicobacter Pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity. Cel. Microbiol. 2008; 10 (3): 781–794.Zealter Z. et al. Analysis of detergent-resistant membranes of Helicobacter Pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity. Cel. Microbiol. 2008; 10 (3): 781–794.Sandifer Q.D. et al. Association may not be causal. Br. Med.J. 1996; 312: 251.Sandifer Q.D. et al. Association may not be causal. Br. Med.J. 1996; 312: 251.Loginov S. V., Kozlova I. V., Shvarc Ju. G. Myocardium repolarization parameters, cardiac rhythm disorders at patients with association of coronary artery disease and gastroesophageal reflux disease in connection of Helicobacter Pylori presence. Vestnik aritmologii 2005; 42: 57–60. Russain (Логинов С.В., Козлова И.В., Шварц Ю.Г. Показатели реполяризации миокарда, нарушения сердечного ритма у пациентов с сочетанием ишемической болезни сердца и гастроэзофагеальной рефлюксной болезни в зависимости от наличия и степени выраженности хеликобактериоза. Вестник аритмологии 2005; 42: 57–60).Loginov S. V., Kozlova I. V., Shvarc Ju. G. Myocardium repolarization parameters, cardiac rhythm disorders at patients with association of coronary artery disease and gastroesophageal reflux disease in connection of Helicobacter Pylori presence. Vestnik aritmologii 2005; 42: 57–60. Russain (Логинов С.В., Козлова И.В., Шварц Ю.Г. Показатели реполяризации миокарда, нарушения сердечного ритма у пациентов с сочетанием ишемической болезни сердца и гастроэзофагеальной рефлюксной болезни в зависимости от наличия и степени выраженности хеликобактериоза. Вестник аритмологии 2005; 42: 57–60).Diomedi M. et al. CagA-positive Helicobacter Pylori strains may influence the natural history of atherosclerotic stroke. Neurology 2004; 63 (5): 800–804.Diomedi M. et al. CagA-positive Helicobacter Pylori strains may influence the natural history of atherosclerotic stroke. Neurology 2004; 63 (5): 800–804.Miyazaki M. et al. Is Helicobacter Pylori infection a risk factor for acute coronary syndromes? J. Infect. 2006; 52 (2): 86–91.Miyazaki M. et al. Is Helicobacter Pylori infection a risk factor for acute coronary syndromes? J. Infect. 2006; 52 (2): 86–91.Kowalski M. et al. Prevalence of Helicobacter Pylori infection in coronary artery disease and effect of its eradication on coronary lumen reduction after percutaneous coronary angioplasty. Dig. Liver Dis. 2001; 33 (3): 222–229.Kowalski M. et al. Prevalence of Helicobacter Pylori infection in coronary artery disease and effect of its eradication on coronary lumen reduction after percutaneous coronary angioplasty. Dig. Liver Dis. 2001; 33 (3): 222–229.Pellicano R. et al. Helicobacter Pylori: from the stomach to the heart. Eur.J. Gastroenterol. Hepatol. 1999; 11 (11): 1335–1337.Pellicano R. et al. Helicobacter Pylori: from the stomach to the heart. Eur.J. Gastroenterol. Hepatol. 1999; 11 (11): 1335–1337.Weydig C. et al. CagA-independent disruption of adherence junction complexes involves E cadherin shedding and implies multiple steps in Helicobacter Pylori pathogenicity. Exp. Cell Res. 2007; 313 (16): 3459–3471.Weydig C. et al. CagA-independent disruption of adherence junction complexes involves E cadherin shedding and implies multiple steps in Helicobacter Pylori pathogenicity. Exp. Cell Res. 2007; 313 (16): 3459–3471.Brandt S. et al. Use of a novel coinfection system reveals a role for Rac1, H Ras, and CrkII phosphorylation in Helicobacter Pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol. Med. Microbiol. 2007; 50: 190–205.Brandt S. et al. Use of a novel coinfection system reveals a role for Rac1, H Ras, and CrkII phosphorylation in Helicobacter Pylori-induced host cell actin cytoskeletal rearrangements. FEMS Immunol. Med. Microbiol. 2007; 50: 190–205.Pattis I. et al. The Helicobacter Pylori CagF protein is a type IV secretion chaperonelike molecule that binds close to the C terminal secretion signal of the CagA effector protein. Microbiology 2007; 153: 2896–2909.Pattis I. et al. The Helicobacter Pylori CagF protein is a type IV secretion chaperonelike molecule that binds close to the C terminal secretion signal of the CagA effector protein. Microbiology 2007; 153: 2896–2909.Kayo S. et al. Oxidized low-density lipoprotein levels circulating in plasma and deposited in the tissues: comparison between Helicobacter Pylori-associated gastritis and acute myocardial infarction. Am. Heart J. 2004; 148 (5): 818–825.Kayo S. et al. Oxidized low-density lipoprotein levels circulating in plasma and deposited in the tissues: comparison between Helicobacter Pylori-associated gastritis and acute myocardial infarction. Am. Heart J. 2004; 148 (5): 818–825.Martusevich A. K., Zimin Ju. V. Role of physical and chemical processes in «microorganism – human» system. Vestnik Sankt-Peterburgskoj gosudarstvennoj medicinskoj akademii im. I. I. Mechnikova 2008; 3: 112–115. Russain (Мартусевич А. К., Зимин Ю.В. Роль физико-химических процессов в системе «микроорганизм – человек». Вестник Санкт-Петербургской государственной медицинской академии им. И. И. Мечникова 2008; 3: 112–115).Martusevich A. K., Zimin Ju. V. Role of physical and chemical processes in «microorganism – human» system. Vestnik Sankt-Peterburgskoj gosudarstvennoj medicinskoj akademii im. I. I. Mechnikova 2008; 3: 112–115. Russain (Мартусевич А. К., Зимин Ю.В. Роль физико-химических процессов в системе «микроорганизм – человек». Вестник Санкт-Петербургской государственной медицинской академии им. И. И. Мечникова 2008; 3: 112–115).Martusevich A.K., Kolevatyh E. P. To the question about microorganism-associated crystallogenesis. Vjatskij medicinskij vestnik 2007; 2–3: 8–22. Russain (Мартусевич А. К., Колеватых Е. П. К вопросу о микробной инициации кристалогенеза. Вятский медицинский вестник 2007; 2–3: 8–22).Martusevich A.K., Kolevatyh E. P. To the question about microorganism-associated crystallogenesis. Vjatskij medicinskij vestnik 2007; 2–3: 8–22. Russain (Мартусевич А. К., Колеватых Е. П. К вопросу о микробной инициации кристалогенеза. Вятский медицинский вестник 2007; 2–3: 8–22).Martusevich A.K. Potential role of crystallogenic bacterial symbiosis in pathogenesis of complicated peptic ulcer. Vestnik Orenburgskogo gosudarstvennogo universiteta 2011; 4: 140–141. Russian (Мартусевич А. К. Потенциальная роль кристаллогенного бактериального симбиоза в патогенезе осложненных форм язвенной болезни//Вестник Оребургского государственного университета. – 2011. – № 4. – С. 140–141).Martusevich A.K. Potential role of crystallogenic bacterial symbiosis in pathogenesis of complicated peptic ulcer. Vestnik Orenburgskogo gosudarstvennogo universiteta 2011; 4: 140–141. Russian (Мартусевич А. К. Потенциальная роль кристаллогенного бактериального симбиоза в патогенезе осложненных форм язвенной болезни//Вестник Оребургского государственного университета. – 2011. – № 4. – С. 140–141).Allen L.-A. H. et al. Phosphoinositide3 kinase мregulates actin polymerization during delayed phagocytosis of Helicobacter Pylori. J. Leukoc.Biol.2005;78 (1):220–230.Allen L.-A. H. et al. Phosphoinositide3 kinase мregulates actin polymerization during delayed phagocytosis of Helicobacter Pylori. J. Leukoc.Biol.2005;78 (1):220–230.

The authors declare that there are no conflicts of interest present.