russjcardiolРоссийский кардиологический журналRussian Journal of Cardiology1560-40712618-7620«SILICEA-POLIGRAF» LLC10.15829/1560-4071-2017-11-93-97russjcardiol-1033Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWЗНАЧЕНИЕ КОПЕПТИНА ДЛЯ ДИАГНОСТИКИ ИНФАРКТА МИОКАРДАSIGNIFICANCE OF COPEPTIN IN DIAGNOSTICS OF MYOCARDIAL INFARCTIONКремневаЛ. В.KremnevaL. V.

Кремнева Людмила В. — доктор медицинских наук, профессор кафедры клинической лабораторной диагностики ФПК и ППС

Kremnevalv01@gmail.comФГБОУ ВО Тюменский государственный медицинский университет Минздрава РоссииРоссияTymensky State Medical UniversityRussian Federation2017091220170119397Copyright © Кремнева Л.В., 20172017Кремнева Л.В.Kremneva L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://russjcardiol.elpub.ru/jour/article/view/1033

В литературном обзоре представлены результаты исследований, посвященных значению нового лабораторного маркера копептина в диагностике инфаркта миокарда (ИМ) и оценке последующего прогноза. Копептин (суррогатный маркер вазопрессина) отражает выраженность эндогенного нейро-гормонального стресса, значимо повышается в крови уже в первый час ИМ и снижается к десятому часу от начала заболевания. Отрицательные значения копептина и тропонина Т позволяют с высокой степенью достоверности исключить ИМ. Степень повышения копептина коррелирует с величиной очага некроза сердечной мышцы и последующим прогнозом заболевания: риском развития сердечной смерти и прогрессирования хронической сердечной недостаточности.

In the review, studies results are presented on the significance of laboratory marker copeptin in diagnostics of myocardial infarction (MI) and further prognosis evaluation. Copeptin (surrogate marker of vasopressin) represents the severity of endogenic neurohormonal stress and significantly increases in blood during the first hour of MI course, declining at tenth hour from onset. Negative values of copeptin and troponin T make it with high grade of credibility to rule out MI. Grade of copeptin increase correlates with the size of myocardium necrosis focus and further prognosis of the disease: sudden death risk and progression of chronic heart failure.

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The authors declare that there are no conflicts of interest present.